ArticleJournal of virology1992
NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 93 citations in OpenAlex.
- Article
- Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells).Cell biology and toxicology · 2010Article
- E1A-CR3 interaction-dependent and -independent functions of mSur2 in viral replication of early region 1A mutants of mouse adenovirus type 1.Journal of virology · 2005Article
- Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.Oncogene · 2004Article
- Efficient generation and amplification of high-capacity adeno-associated virus/adenovirus hybrid vectors.Journal of virology · 2002Article
- Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10.Journal of virology · 2002Article
- Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression.Journal of virology · 2000Article
- Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.Journal of virology · 2000Article
- Review
- Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver.Journal of virology · 1998Article
- Overexpression of C/EBPbeta represses human papillomavirus type 18 upstream regulatory region activity in HeLa cells by interfering with the binding of TATA-binding protein.Journal of virology · 1998Article
- Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication.Journal of virology · 1997Article
- Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses.Journal of virology · 1997Article
- Effect of the E4 region on the persistence of transgene expression from adenovirus vectors.Journal of virology · 1997Article
- Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo.Journal of virology · 1996Article
- A novel C/EBP beta-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region.Journal of virology · 1996Article
- Strategies for cancer gene therapy using adenoviral vectors.Journal of molecular medicine (Berlin, Germany) · 1996Review
- Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit.Journal of virology · 1996Article
- The human topoisomerase I gene promoter is regulated by NF-IL6.Molecular and cellular biology · 1995Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
A cDNA encoding NF-IL6, an interleukin-6 (IL-6)-regulated human nuclear factor of the C/EBP family, is demonstrated to complement the transactivation function of E1A. The endogenous NF-IL6 level varies according to cell type and correlates positively with an IL-6-regulated cellular E1A-substituting activity that was described recently (J.M. Spergel and S. Chen-Kiang, Proc. Natl. Acad. Sci. USA 88:6472-6476, 1991). When expressed by transfection in cells which contain low levels of NF-IL6 and are incapable of complementing the function of E1A proteins, NF-IL6 also transactivates the E1A-responsive E2ae and E1B promoters, to the same magnitude as E1A. Activation by NF-IL6 is concentration dependent and sequence specific: mutational studies of the E2ae promoter suggest that the promoter-proximal NF-IL6 recognition site functions as a dominant negative regulatory site whereas the promoter-distal NF-IL6 recognition site is positively regulated at low NF-IL6 concentrations and negatively regulated when the NF-IL6 level is high. Consistent with these functions, NF-IL6 alone is sufficient to complement an E1A deletion mutant dl312 in viral infection, when expressed at appropriate concentrations. These results identify NF-IL6 as a sequence-specific cellular nuclear factor which regulates E1A-responsive genes in the absence of E1A.
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