ArticleVirology1992
MHV S peplomer protein expressed by a recombinant vaccinia virus vector exhibits IgG Fc-receptor activity.
Article in Virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Identification of novel functional regions within the spike glycoprotein of MHV-A59 based on a bioinformatics approach.Virus research · 2014Article
- Identification of the receptor for FGL2 and implications for susceptibility to mouse hepatitis virus (MHV-3)-induced fulminant hepatitis.Advances in experimental medicine and biology · 2006Article
- Oligoclonal T cells are infiltrating the brains of children with AIDS: sequence analysis reveals high proportions of identical beta-chain T-cell receptor transcripts.Clinical and experimental immunology · 2005Article
- Antigenicity and receptor-binding ability of recombinant SARS coronavirus spike protein.Biochemical and biophysical research communications · 2004Article
- Theiler's virus infection: a model for multiple sclerosis.Clinical microbiology reviews · 2004Review
- Decreased expression of the CD3zeta chain in T cells infiltrating the synovial membrane of patients with osteoarthritis.Clinical and diagnostic laboratory immunology · 2004Article
- Severe acute respiratory syndrome coronavirus and viral mimicry.Lancet (London, England) · 2003Article
- Presence of oligoclonal T cells in cerebrospinal fluid of a child with multiphasic disseminated encephalomyelitis following hepatitis A virus infection.Clinical and diagnostic laboratory immunology · 2001Article
- A role for naturally occurring variation of the murine coronavirus spike protein in stabilizing association with the cellular receptor.Journal of virology · 1997Article
- The molecular biology of coronaviruses.Advances in virus research · 1997Review
- Immunology of Theiler's murine encephalomyelitis virus infection.Immunologic research · 1995Review
- Immunopathogenesis of juvenile rheumatoid arthritis: role of T cells and MHC.Immunologic research · 1995Review
- Article
- T-cell antigen receptors in rheumatoid arthritis.Immunologic research · 1994Review
- A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination.Veterinary microbiology · 1993Review
- Microheterogeneity of S-glycoprotein of mouse hepatitis virus temperature-sensitive mutants.Journal of virological methods · 1992Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have previously shown that cells infected with mouse hepatitis virus (MHV) bind rabbit, mouse, and rat IgG by the Fc portion of the IgG molecule. This Fc-binding activity appeared to be mediated by the MHV S protein. S protein could also be precipitated from MHV-infected cells by a monoclonal antibody directed against the murine Fc gamma receptor (Fc gamma R). To prove definitively that the S protein mediates Fc-binding activity, we have expressed the MHV S protein utilizing recombinant vaccinia viruses. The anti-Fc gamma R monoclonal antibody, 2.4G2, precipitated recombinant S protein in cells of murine, human, and rabbit origin. Since the anti-Fc receptor monoclonal antibody does not react with human and rabbit Fc receptors these results demonstrate that the epitope recognized by this antibody is carried on the MHV S protein and is not murine in origin. Examination of various MHV isolates and escape mutants failed to identify the precise sequences in S responsible for the molecular mimicry of the murine Fc gamma R. These data are consistent with the hypothesis that a previously identified region of similarity between the S protein and the Fc gamma R mediates this activity. The Fc binding activity of S was expressed on the cell surface, since MHV-JHM-infected cells, but not uninfected cells, formed rosettes with anti-sheep red blood cell (SRBC) antibody-coated SRBC. The anti-Fc gamma R monoclonal antibody neutralized MHV-JHM and inhibited syncytium formation induced by the MHV S protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.