ReviewGlycoconjugate journal
Investigation of hyaluronan function in the mouse through targeted mutagenesis.
Review in Glycoconjugate journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- The role of hyaluronan in renal cell carcinoma.Frontiers in immunology · 2023Review
- Dysregulation of Hyaluronan Homeostasis During White Matter Injury.Neurochemical research · 2020Review
- Article
- Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism.World journal of biological chemistry · 2015Review
- A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Therapeutic targeting of hyaluronan in the tumor stroma.Cancers · 2012Article
- Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis.The Journal of biological chemistry · 2012Article
- Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.The Journal of investigative dermatology · 2012Article
- Neural stem cell niches: roles for the hyaluronan-based extracellular matrix.Frontiers in bioscience (Scholar edition) · 2011Review
- Hyaluronan as an immune regulator in human diseases.Physiological reviews · 2011Review
- The extracellular matrix in development and morphogenesis: a dynamic view.Developmental biology · 2010Review
- Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer.Developmental biology · 2007Article
- Gammadelta T cell-induced hyaluronan production by epithelial cells regulates inflammation.The Journal of experimental medicine · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It has become increasingly apparent that the high molecular mass glycosaminoglycan, hyaluronan (HA), is required for many morphogenetic processes during vertebrate development. This renewed understanding of the various developmental roles for HA, has come about largely through the advent of gene targeting approaches in the mouse. To date, mutations have been engineered in the enzymes responsible for biosynthesis and degradation and for those proteins that bind to HA within the extracellular matrix and at the cell surface. Collectively, the phenotypes resulting from these mutations demonstrate that HA is critical for normal mammalian embryogenesis and for various processes in postnatal and adult life (Table 1). In this article we will review our progress in understanding the biological functions for HA through targeted mutagenesis of the HA synthase 2 (Has2) and 3 (Has3) genes. Data that has been obtained from a conventional targeted disruption of the Has2 gene, is presented in an accompanying review by Camenisch and McDonald. More specifically, in this review we will provide an overview of the conditional gene targeting strategy being used to create tissue-specific deficiencies in Has2 function, along with our progress in understanding the role for Has3-dependent HA biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.