ReviewGlycoconjugate journal
Hyaluronan: genetic insights into the complex biology of a simple polysaccharide.
Review in Glycoconjugate journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 92 citations in OpenAlex.
- Prognostic implications of stromal hyaluronic acid protein expression in resected oropharyngeal and oral cavity cancers.The Korean journal of internal medicine · 2020Article
- Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Biological roles of glycans.Glycobiology · 2017Review
- Hyaluronan based hydrogels provide an improved model to study megakaryocyte-matrix interactions.Experimental cell research · 2016Article
- Hyaluronan as a therapeutic target in human diseases.Advanced drug delivery reviews · 2016Review
- The Hyaluronic Acid-HDAC3-miRNA Network in Allergic Inflammation.Frontiers in immunology · 2015Review
- Regioselective Benzylation of 2-Deoxy-2-Aminosugars Using Crown Ethers: Application to a Shortened Synthesis of Hyaluronic Acid Oligomers.Advanced synthesis & catalysis · 2014Article
- Hyaluronic acid promotes angiogenesis by inducing RHAMM-TGFβ receptor interaction via CD44-PKCδ.Molecules and cells · 2012Article
- Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.The Journal of investigative dermatology · 2012Article
- Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells.PloS one · 2012Article
- Significance of elevated levels of collagen type IV and hyaluronic acid in gastric juice and serum in gastric cancer and precancerous lesion.Digestive diseases and sciences · 2011Article
- Hyaluronan as an immune regulator in human diseases.Physiological reviews · 2011Review
- Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.Physiological reviews · 2010Review
- Chondroitin sulfate expression is required for cardiac atrioventricular canal formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Size-dependent regulation of Snail2 by hyaluronan: its role in cellular invasion.Glycobiology · 2009Article
- Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes.Osteoarthritis and cartilage · 2009Article
- BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression.Cancer science · 2008Review
- Article
- Heart valve development: endothelial cell signaling and differentiation.Circulation research · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
It is appropriate that this review should appear in a volume dedicated to Mert Bernfield. Much of my interest in the cell biology of the extracellular matrix, particularly during development, echoes Mert's pioneering studies. His kind but provocative questioning during meetings is especially missed. The glycosaminoglycan hyaluronan is ubiquitous, and is especially abundant during embryogenesis. Hydrated matrices rich in hyaluronan expand the extracellular space, facilitating cell migration. The viscoelastic properties of hyaluronan are also essential for proper function of cartilage and joints. Recent understanding of hyaluronan biology has benefited from the identification of genes encoding hyaluronan synthases and hyaluronidases, genetic analysis of the roles of hyaluronan during development, elucidation of the biochemical mechanisms of hyaluronan synthesis, and by studies of human genetics and tumors. This review focuses on recent studies utilizing hyaluronan-deficient, gene targeted mice with null alleles for the principal source of hyaluronan during mid-gestation, hyaluronan synthase-2 (has-2).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.