Evidence map›Paper›PMID 12975609›Full record

ReviewGlycoconjugate journal

Syndecan-4: dispensable or indispensable?

Sarah A Wilcox-Adelman, Fabienne Denhez, Tokuro Iwabuchi, Stefania Saoncella, Enzo Calautti, Paul F Goetinck

Abstract readReview
PubMed Publisher
In one paragraph

Review in Glycoconjugate journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The glomerular basement membrane as a model system to study the bioactivity of heparan sulfate glycosaminoglycans.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2012
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion.The international journal of biochemistry & cell biology · 2009
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sarah A Wilcox-AdelmanCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. sarah.wilcox-adelman@cbrc2.mgh.harvard.edu
Fabienne Denhez
Tokuro Iwabuchi
Stefania Saoncella
Enzo Calautti
Paul F Goetinck
Harvard University · USMassachusetts General Hospital · US

Funding

SYNDECAN-4 SIGNALING IN CELL-MATRIX INTERACTIONSR01HD037490 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI GOETINCK, PAUL F · 1999 to 2008
$3.3M
NICHD NIH HHS HD-37490
6 · The paper itself

Abstract

Studies examining the role of the cell-surface heparan sulfate proteoglycan syndecan-4 have yielded a plethora of information regarding its role in both cell-matrix and growth-factor mediated signaling events. Many of the initial conclusions drawn from such research placed syndecan-4 in a keystone position within various signaling pathways though the generation of syndecan-4 null mice have surprised many in the field by indicating otherwise. These contradictory results place researchers in the frustrating and yet exhilarating position of still asking the question, "What role does syndecan-4 play in life?"

Indexed as

AnimalsCell MovementFocal AdhesionsGene ExpressionGrowth SubstancesHeparan Sulfate ProteoglycansMembrane GlycoproteinsMiceMice, KnockoutProtein Kinase CProteoglycansSignal TransductionSyndecan-4Growth SubstancesHeparan Sulfate ProteoglycansMembrane GlycoproteinsProtein Kinase CProteoglycansSdc4 protein, mouseSyndecan-4

Identifiers

PMID12975609
OpenAlexW2062686838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.