ArticleThe Journal of clinical investigation2003
Turnover of lymphocytes and conceptual paradigms in HIV infection.
Article in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 130 citations in OpenAlex.
- Analysis of the Endogenous Deoxynucleoside Triphosphate Pool in HIV-Positive and -Negative Individuals Receiving Tenofovir-Emtricitabine.Antimicrobial agents and chemotherapy · 2016Trial
- Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment.The Journal of clinical investigation · 2009Trial
- HIV-1 activates oxidative phosphorylation in infected CD4 T cells in a human tonsil explant model.Frontiers in immunology · 2023Article
- MicroRNA Involvement in Signaling Pathways During Viral Infection.Frontiers in cell and developmental biology · 2020Review
- Immunological Paradigms, Mechanisms, and Models: Conceptual Understanding Is a Prerequisite to Effective Modeling.Frontiers in immunology · 2019Review
- Dynamics of Lymphocyte Reconstitution After Hematopoietic Transplantation During Chronic Lymphocytic Choriomeningitis Virus Infection.AIDS research and human retroviruses · 2018Article
- Lack of concordance between residual viremia and viral variants driving de novo infection of CD4(+) T cells on ART.Retrovirology · 2016Article
- The X awakens: multifactorial ramifications of sex-specific differences in HIV-1 infection.Journal of virus eradication · 2016Article
- Baseline CD4+ T cell counts correlates with HIV-1 synonymous rate in HLA-B*5701 subjects with different risk of disease progression.PLoS computational biology · 2014Article
- Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.Journal of virology · 2014Article
- The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).Molecular neurobiology · 2014Review
- Novel HIV-1 miRNAs stimulate TNFα release in human macrophages via TLR8 signaling pathway.PloS one · 2014Article
- Immune activation and collateral damage in AIDS pathogenesis.Frontiers in immunology · 2013Review
- Conditionally-live attenuated SIV upregulates global T effector memory cell frequency under replication permissive conditions.Retrovirology · 2013Article
- Candida colonisation in asymptomatic HIV patients attending a tertiary hospital in Benin City, Nigeria.The Libyan journal of medicine · 2013Article
- Genetic variation and HIV-associated neurologic disease.Advances in virus research · 2013Review
- Role of PD-1 in HIV pathogenesis and as target for therapy.Current HIV/AIDS reports · 2012Review
- Loss of CD127 & increased immunosenescence of T cell subsets in HIV infected individuals.The Indian journal of medical research · 2011Article
- Dissociation of CD154 and cytokine expression patterns in CD38+ CD4+ memory T cells in chronic HIV-1 infection.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Similar impact of CD8+ T cell responses on early virus dynamics during SIV infections of rhesus macaques and sooty mangabeys.PLoS computational biology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role of generalized immune system activation. The observation that increases in T cell turnover seen in HIV-infected individuals primarily reflect increased proliferation of effector-memory T cells supports the concept that chronic immune activation plays a prominent, if not predominant, role in the pathogenesis of AIDS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.