ArticleHeart (British Cardiac Society)2003
Risk progression to chronic Chagas cardiomyopathy: influence of male sex and of parasitaemia detected by polymerase chain reaction.
Article in Heart (British Cardiac Society), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 6 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The efficacy and safety of benznidazole in adults with seropositive indeterminate form, Trypanosoma cruzi infection: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease - 2023.Arquivos brasileiros de cardiologia · 2023Guideline
- Interleukin 10 Polymorphisms as Risk Factors for Progression to Chagas Disease Cardiomyopathy: A Case-Control Study and Meta-Analysis.Frontiers in immunology · 2022Pooled it
- Association BetweenFrontiers in cardiovascular medicine · 2021Pooled it
- Risk of Chronic Cardiomyopathy Among Patients With the Acute Phase or Indeterminate Form of Chagas Disease: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Increased mortality attributed to Chagas disease: a systematic review and meta-analysis.Parasites & vectors · 2016Pooled it
- Two-year death prediction models among patients with Chagas Disease using machine learning-based methods.PLoS neglected tropical diseases · 2022Trial
- A SpecificFrontiers in immunology · 2020Trial
- Review
- Long-Lasting Antibody and CD8Vaccines · 2026Article
- Chagas Heart Disease: Social Determinants and Delayed Diagnosis.JACC. Case reports · 2026Article
- Sex in Immune Cells and Parasitic Diseases - A Complex Relationship.Immunological reviews · 2026Review
- Clinical Progression of Cardiac ChronicPathogens (Basel, Switzerland) · 2025Article
- Sex Differences in Chagas Cardiomyopathy: a Comprehensive Review.Current heart failure reports · 2025Review
- Sexual dimorphism-driven differences are overcome in a preclinical vaccine model againstFrontiers in immunology · 2025Article
- Bridging the Nervous-Endocrine System and Immune Response, in Human Chagas Disease Pathology.Neuroimmunomodulation · 2025Review
- Clinical features of Chagas disease progression and severity.Lancet regional health. Americas · 2024Review
- Increased Natural Killer (NK)-cell cytotoxicity and Trypanosoma cruzi-specific memory B cells in subjects with discordant serology for Chagas disease.Biochimica et biophysica acta. Molecular basis of disease · 2024Article
- Quantitative PCR as a marker for preemptive therapy and its role in therapeutic control in Trypanosoma cruzi/HIV coinfection.PLoS neglected tropical diseases · 2024Article
- Screening for Chagas disease from the electrocardiogram using a deep neural network.PLoS neglected tropical diseases · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymerase chain reaction (PCR) allows detection of Trypanosoma cruzi in blood throughout the course of Chagas' disease.
objectiveTo determine whether T cruzi DNA detected by PCR is associated with progression to chronic Chagas cardiomyopathy.
designProspective cohort study.
settingA tertiary care centre in Argentina. PATIENTS: 56 consecutive patients with chronic T cruzi infection.
methodsClinical examination, ECG, and Doppler echocardiography were carried out at baseline and at the end of the follow up. Detection of T cruzi DNA by PCR amplifying a nuclear sequence was undertaken in all patients at baseline.
main outcome measuresProgression was defined as death from chronic cardiomyopathy or the presence of a new ECG or left ventricular echocardiographic abnormality at the end of follow up.
resultsThe 56 patients (21 male, 35 female; mean (SD) age, 56.0 (11.3) years) were followed for a mean 936.3 (244.39) days. Progression to cardiomyopathy was detected in 12 patients (21.4%). Three of these patients died after baseline evaluation. Univariate analysis showed that a positive PCR (relative risk 4.09, 95% confidence interval (CI) 1.60 to 9.85) and male sex (5.00, 95% CI 1.65 to 15.73) were associated with progression. Multivariable logistic regression indicated that both sex and PCR were independent variables affecting the outcome.
conclusionsIn a cohort of seropositive individuals, patients with T cruzi DNA detected by PCR and male patients were at higher risk of progression. These results highlight the importance of T cruzi in the pathophysiology of chronic cardiomyopathy.
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