ArticleGenome research2003
Mystery of intron gain.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- Discovering Intron Gain Events in Humans Through Large-Scale Evolutionary Comparisons.Genome biology and evolution · 2025Article
- Genome-wide identification and expression analysis of the coronatine-insensitive 1 (COI1) gene family in response to biotic and abiotic stresses in Saccharum.BMC genomics · 2022Article
- Comprehensive database and evolutionary dynamics of U12-type introns.Nucleic acids research · 2020Article
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- Article
- Identifying the mechanisms of intron gain: progress and trends.Biology direct · 2012Review
- Mechanisms of intron gain and loss in Drosophila.BMC evolutionary biology · 2011Article
- Article
- Intron creation and DNA repair.Cellular and molecular life sciences : CMLS · 2011Review
- Nonsense-mediated decay enables intron gain in Drosophila.PLoS genetics · 2010Article
- An overview of the introns-first theory.Journal of molecular evolution · 2009Article
- A maximum likelihood method for reconstruction of the evolution of eukaryotic gene structure.Methods in molecular biology (Clifton, N.J.) · 2009Review
- Oscheius tipulae as an example of eEF1A gene diversity in nematodes.Journal of molecular evolution · 2008Article
- Alternative splicing: a missing piece in the puzzle of intron gain.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Spliceosomal introns as tools for genomic and evolutionary analysis.Nucleic acids research · 2008Review
- Development and validation of a Viviparous-1 STS marker for pre-harvest sprouting tolerance in Chinese wheats.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2007Article
- Alternate intron processing of family 5 endoglucanase transcripts from the genus Phytophthora.Current genetics · 2007Article
- Three distinct modes of intron dynamics in the evolution of eukaryotes.Genome research · 2007Article
- Large-scale intron conservation and order-of-magnitude variation in intron loss/gain rates in apicomplexan evolution.Genome research · 2006Article
- The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate?Biology direct · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For nearly 15 years, it has been widely believed that many introns were recently acquired by the genes of multicellular organisms. However, the mechanism of acquisition has yet to be described for a single animal intron. Here, we report a large-scale computational analysis of the human, Drosophila melanogaster, Caenorhabditis elegans, and Arabidopsis thaliana genomes. We divided 147,796 human intron sequences into batches of similar lengths and aligned them with each other. Different types of homologies between introns were found, but none showed evidence of simple intron transposition. Also, 106,902 plant, 39,624 Drosophila, and 6021 C. elegans introns were examined. No single case of homologous introns in nonhomologous genes was detected. Thus, we found no example of transposition of introns in the last 50 million years in humans, in 3 million years in Drosophila and C. elegans, or in 5 million years in Arabidopsis. Either new introns do not arise via transposition of other introns or intron transposition must have occurred so early in evolution that all traces of homology have been lost.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.