ArticleBMC pharmacology2003
Arterial expression of 5-HT2B and 5-HT1B receptors during development of DOCA-salt hypertension.
Article in BMC pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 47 citations in OpenAlex.
- Serotonin Receptors in Myocardial Infarction: Friend or Foe?ACS chemical neuroscience · 2024Review
- Synergistic Interaction of 5-HTInternational journal of molecular sciences · 2023Article
- Molecular and cellular basis of praziquantel action in the cardiovascular system.American journal of physiology. Cell physiology · 2023Article
- International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.Pharmacological reviews · 2021Review
- Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations.Journal of animal science · 2018Article
- 5-HT causes splanchnic venodilation.American journal of physiology. Heart and circulatory physiology · 2017Article
- Multiple activation mechanisms of serotonin-mediated contraction in the carotid arteries obtained from spontaneously hypertensive rats.Pflugers Archiv : European journal of physiology · 2016Article
- Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects.Current neuropharmacology · 2014Article
- Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase.Experimental & molecular medicine · 2013Article
- Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells.Frontiers in pharmacology · 2013Article
- 5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved.BMC pharmacology · 2012Article
- Serotonin and blood pressure regulation.Pharmacological reviews · 2012Review
- 5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes.Experimental diabetes research · 2012Article
- 5-hydroxtryptamine receptors in systemic hypertension: an arterial focus.Cardiovascular therapeutics · 2011Review
- The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
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2 authors at 1 institution in 1 country.
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Abstract
background5-hydroxytryptamine (5-HT)2B and 5-HT1B receptors are upregulated in arteries from hypertensive DOCA-salt rats and directly by mineralocorticoids. We hypothesized that increased 5-HT2B and 5-HT1B receptor density and contractile function would precede increased blood pressure in DOCA-high salt rats. We performed DOCA-salt time course (days 1, 3, 5 and 7) studies using treatment groups of: DOCA-high salt, DOCA-low salt, Sham and Sham-high salt rats.
resultsIn isolated-tissue baths, DOCA-high salt aorta contracted to the 5-HT2B receptor agonist BW723C86 on day 1; Sham aorta did not contract. The 5-HT1B receptor agonist CP93129 had no effect in arteries from any group. On days 3, 5 and 7 CP93129 and BW723C86 contracted DOCA-high salt and Sham-high salt aorta; Sham and DOCA-low salt aorta did not respond. Western analysis of DOCA-high salt aortic homogenates revealed increased 5-HT2B receptor levels by day 3; 5-HT1B receptor density was unchanged. Aortic homogenates from the other groups showed unchanged 5-HT2B and 5-HT1B receptor levels.
conclusionThese data suggest that functional changes of 5-HT2B but not 5-HT1B receptors may play a role in the development of DOCA-salt hypertension.
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