Trial reportClinical and experimental immunology2003
Circulating adiponectin levels during human endotoxaemia.
Trial report in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Serum Adiponectin Predicts COVID-19 Severity.Biomedicines · 2024Article
- Preliminary Report on the Influence of Acute Inflammation on Adiponectin Levels in Older Inpatients with Different Nutritional Status.International journal of molecular sciences · 2024Article
- Changes in the Secretion of Melatonin and Selected Adipokines during the Progression of Parkinson's Disease-Preliminary Studies.Metabolites · 2023Article
- Fat tissue regulates the pathogenesis and severity of cardiomyopathy in murine chagas disease.PLoS neglected tropical diseases · 2021Article
- Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists.Frontiers in immunology · 2020Article
- Lipopolysaccharide induces a downregulation of adiponectin receptors in-vitro and in-vivo.PeerJ · 2015Article
- Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis.Innate immunity · 2014Article
- A single bout of downhill running transiently increases HOMA-IR without altering adipokine response in healthy adult women.European journal of applied physiology · 2013Article
- Clinical review: adiponectin biology and its role in inflammation and critical illness.Critical care (London, England) · 2011Review
- Adipose tissue, diabetes and Chagas disease.Advances in parasitology · 2011Review
- Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock.Intensive care medicine · 2010Article
- Treatment with TNF-alpha and IFN-gamma alters the activation of SER/THR protein kinases and the metabolic response to IGF-I in mouse c2c12 myogenic cells.Cellular & molecular biology letters · 2010Article
- Low circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infection.Journal of perinatal medicine · 2010Article
- Chagas disease, adipose tissue and the metabolic syndrome.Memorias do Instituto Oswaldo Cruz · 2009Article
- Changes in serum adiponectin concentrations in critical illness: a preliminary investigation.Critical care (London, England) · 2009Article
- Perspectives on adipose tissue, chagas disease and implications for the metabolic syndrome.Interdisciplinary perspectives on infectious diseases · 2009Article
- Adipocyte, adipose tissue, and infectious disease.Infection and immunity · 2007Review
- Circulating YKL-40 levels during human endotoxaemia.Clinical and experimental immunology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adiponectin, an adipocytokine secreted by fat tissue, may prevent development of diabetes type II, as high adiponectin levels are linked with insulin sensitivity. In contrast, tumour necrosis factor (TNF)-alpha, which is also produced by fat tissue, leads to insulin resistance and furthermore inhibits adiponectin mRNA production and secretion of the protein. However, adiponectin also negatively regulates TNF-alpha levels. Therefore, we set out to test whether an infusion of endotoxin would influence circulating adiponectin levels in healthy human subjects. Twenty-three healthy human subjects were injected with endotoxin (2 ng/kg body weight); eight of these subjects were also injected with saline and served as controls. Plasma levels of adiponectin, TNF-alpha and interleukin-6 were measured at 0, 1.5, 2, 4, 8 and 24 h. TNF-alpha and interleukin-6 levels peaked at 1.5 h and 2 h, respectively. Control subjects injected with saline showed a decrease in adiponectin plasma levels with time (P < 0.05) presumably owing to the effect of fasting or physical inactivity. However, there was no change in adiponectin plasma levels in endotoxin injected subjects, thus the effect of fasting was opposed. In conclusion, circulating adiponectin levels are reduced during a resting and fasting state, an effect reversed by endotoxin injection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.