ArticleAmerican journal of human genetics2003
Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
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Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto's thyroiditis: a meta-analysis.Scientific reports · 2017Pooled it
- Polymorphisms in the ADRB2 gene and Graves disease: a case-control study and a meta-analysis of available evidence.BMC medical genetics · 2009Pooled it
- Different clinical autoimmune polyglandular syndrome phenotypes among patients with thyroid diseases.Journal of endocrinological investigation · 2026Article
- Traditional Chinese Medicine as an Adjunct in Hyperthyroidism Management: A Narrative Review of Pathophysiology, Proposed Mechanisms, and Clinical Evidence.International journal of general medicine · 2026Review
- Autoimmune thyroid disease in inborn errors of immunity: a retrospective perspective.Orphanet journal of rare diseases · 2025Article
- A Flexible Mouse Model of Autoimmune Thyroiditis Induced by Immunization with an Adenovirus Containing Full-Length Thyroglobulin cDNA.Current protocols · 2024Article
- The genetics of Graves' disease.Reviews in endocrine & metabolic disorders · 2024Review
- Review
- Identification of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases by Deep Sequencing of Linked Loci.The Journal of clinical endocrinology and metabolism · 2021Article
- Limited Genetic Overlap Between Overt Hashimoto's Thyroiditis and Graves' Disease in Twins: A Population-based Study.The Journal of clinical endocrinology and metabolism · 2021Article
- Screening of Graves' disease susceptibility genes by whole exome sequencing in a three-generation family.BMC medical genomics · 2021Article
- Precision Medicine in Graves' Disease and Ophthalmopathy.Frontiers in pharmacology · 2021Review
- A Novel Mouse Model of Autoimmune Thyroiditis Induced by Immunization with Adenovirus Containing Full-Length Thyroglobulin cDNA: Implications to Genetic Studies of Thyroid Autoimmunity.Thyroid : official journal of the American Thyroid Association · 2020Article
- Identification of novel HLA-A0201-restricted T-cell epitopes against thyroid antigens in autoimmune thyroid diseases.Endocrine · 2020Article
- Association of variant on the promoter of cluster of differentiation 74 in graves disease and graves ophthalmopathy.Bioscience reports · 2020Article
- Latent autoimmune thyroid disease.Journal of translational autoimmunity · 2020Article
- Fine mapping of thyroglobulin gene identifies two independent risk loci for Graves' disease in Chinese Han population.Annals of translational medicine · 2019Article
- Congenital hypothyroidism due to thyroglobulin deficiency: a case report with a novel mutation in TG gene.Annals of pediatric endocrinology & metabolism · 2019Article
- Linkage Analysis of the Chromosome 5q31-33 Region Identifies JAKMIP2 as a Risk Factor for Graves' Disease in the Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Molecular Insights Into the Relationship Between Autoimmune Thyroid Diseases and Breast Cancer: A Critical Perspective on Autoimmunity and ER Stress.Frontiers in immunology · 2019Review
23 more citing papers are in PubMed but not listed here.
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Abstract
The autoimmune thyroid diseases (AITDs), comprising Graves disease (GD) and Hashimoto thyroiditis (HT), develop as a result of a complex interaction between predisposing genes and environmental triggers. Previously, we identified six loci that showed evidence for linkage with AITD in a data set of 56 multiplex families. The goals of the present study were to replicate/reject the previously identified loci before fine mapping and sequencing the candidate genes in these regions. We performed a whole-genome linkage study in an expanded data set of 102 multiplex families with AITD (540 individuals), through use of 400 microsatellite markers. Seven loci showed evidence for linkage to AITD. Three loci, on chromosomes 6p, 8q, and 10q, showed evidence for linkage with both GD and HT (maximum multipoint heterogeneity LOD scores [HLOD] 2.0, 3.5, and 4.1, respectively). Three loci showed evidence for linkage with GD: on 7q (HLOD 2.3), 14q (HLOD 2.1), and 20q (LOD 3.3, in a subset of the families). One locus on 12q showed evidence of linkage with HT, giving an HLOD of 3.4. Comparison with the results obtained in the original data set showed that the 20q (GD-2) and 12q (HT-2) loci continued to show evidence for linkage in the expanded data set; the 6p and 14q loci were located within the same region as the previously identified 6p and 14q loci (AITD-1 and GD-1, respectively), but the Xq (GD-3) and 13q (HT-1) loci were not replicated in the expanded data set. These results demonstrated that multiple genes may predispose to GD and HT and that some may be common to both diseases and some are unique. The loci that continue to show evidence for linkage in the expanded data set represent serious candidate regions for gene identification.
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