ArticleProceedings of the National Academy of Sciences of the United States of America2003
Direct observation of dipolar couplings between distant protons in weakly aligned nucleic acids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The use of residual dipolar coupling in studying proteins by NMR.Topics in current chemistry · 2012Review
- Measurement of (1)H-(15)N and (1)H-(13)C residual dipolar couplings in nucleic acids from TROSY intensities.Journal of biomolecular NMR · 2011Article
- Nuclear magnetic resonance analysis of protein-DNA interactions.Journal of the Royal Society, Interface · 2011Review
- Facile measurement of ¹H-¹5N residual dipolar couplings in larger perdeuterated proteins.Journal of biomolecular NMR · 2010Article
- Measurement of imino 1H-1H residual dipolar couplings in RNA.Journal of biomolecular NMR · 2009Article
- Crystallographic analysis of a sex-specific enhancer element: sequence-dependent DNA structure, hydration, and dynamics.Journal of molecular biology · 2009Article
- Sensitivity-optimized experiment for the measurement of residual dipolar couplings between amide protons.Journal of biomolecular NMR · 2007Article
- Accurate measurement of 15N-13C residual dipolar couplings in nucleic acids.Journal of biomolecular NMR · 2005Article
- Improved detection of long-range residual dipolar couplings in weakly aligned samples by Lee-Goldburg decoupling of homonuclear dipolar truncation.Journal of biomolecular NMR · 2004Article
- Resolution-optimized NMR measurement of (1)D(CH), (1)D(CC) and (2)D(CH) residual dipolar couplings in nucleic acid bases.Journal of biomolecular NMR · 2004Article
- Experiments for correlating quaternary carbons in RNA bases.Journal of biomolecular NMR · 2004Article
- DNA A-tract bending in three dimensions: solving the dA4T4 vs. dT4A4 conundrum.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Under conditions where macromolecules are aligned very weakly with respect to an external magnetic field, Brownian diffusion no longer averages internuclear dipole-dipole interactions to zero. The resulting residual dipolar coupling, although typically 3 orders of magnitude weaker than in a fully aligned sample, can readily be measured by solution NMR methods. To date, application of this idea has focused primarily on pairs of nuclei separated by one or two covalent bonds, where the internuclear separation is known and the measured dipolar coupling provides direct information on the orientation of the internuclear vector. A method is described that allows observation of dipolar interactions over much larger distances. By decoupling nearest-neighbor interactions, it is readily possible to observe direct dipolar interactions between protons separated by up to 12 A. The approach is demonstrated for the DNA dodecamer d(CGCGAATTCGCG)2, where direct interactions are observed between protons up to three base pairs apart.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.