ArticleProceedings of the National Academy of Sciences of the United States of America2003
Mathematical models of RNA silencing: unidirectional amplification limits accidental self-directed reactions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Analysis and simulation of a novel stochastic RNA silencing model.Scientific reports · 2025Article
- Mathematical model of RNA-directed DNA methylation predicts tuning of negative feedback required for stable maintenance.Open biology · 2024Article
- Article
- Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways.bioRxiv : the preprint server for biology · 2024Article
- Key Features in the Design and Function of Nanocarriers for Intranasal Administration of Gene Therapy in Huntington Disease.Journal of nanotechnology and nanomaterials · 2023Article
- Modelling cassava production and pest management under biotic and abiotic constraints.Plant molecular biology · 2022Review
- Kinetics ofJournal of drug delivery science and technology · 2021Article
- RNAi revised--target mRNA-dependent enhancement of gene silencing.Nucleic acids research · 2015Article
- Non-Catalytic RISCs and Kinetics Determine Mammalian siRNA Sub-Cellular Localization.PloS one · 2015Article
- Estimate hidden dynamic profiles of siRNA effect on apoptosis.BMC bioinformatics · 2013Article
- Article
- Subcellular fate and off-target effects of siRNA, shRNA, and miRNA.Pharmaceutical research · 2011Review
- Optimal viral strategies for bypassing RNA silencing.Journal of the Royal Society, Interface · 2011Article
- Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppression.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- RNA silencing can explain chlorotic infection patterns on plant leaves.BMC systems biology · 2008Article
- Maintaining the silence: reflections on long-term RNAi.Drug discovery today · 2008Review
- Modeling recursive RNA interference.PLoS computational biology · 2008Article
- The dynamics and efficacy of antiviral RNA silencing: A model study.BMC systems biology · 2008Article
- Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging.Nucleic acids research · 2006Article
- The RNA silencing pathway: the bits and pieces that matter.PLoS computational biology · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
RNA silencing, found broadly throughout the eukaryotes, posttranscriptionally suppresses the expression of "aberrant" genes including those of many viruses and transposons. Similar to the specific immune system of vertebrates, RNA silencing works by generating specific responses against foreign elements and rapidly amplifying these responses to clear or otherwise inactivate the threat. Also like the vertebrate immune system, RNA-silencing systems risk making mistakes and mounting undesirable responses against the self. We develop a set of mathematical models of RNA silencing. We show that current models of RNA silencing do little to explain what prevents mistaken reactions from silencing vital organismal genes. We extend the basic models to show that the presumed unidirectional nature of the amplification process (namely, unidirectional RNA-directed RNA polymerase-mediated synthesis of secondary double-stranded RNA as observed in Caenorhabditis elegans) serves as a "safety mechanism" that safeguards against accidental generation of damaging self-directed reactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.