ArticleMolecular biology of the cell2003
Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Physiological adventures inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Membrane trafficking alterations in breast cancer progression.Frontiers in cell and developmental biology · 2024Review
- Impact of C-terminal truncations in the Arabidopsis Rab escort protein (REP) on REP-Rab interaction and plant fertility.The Plant journal : for cell and molecular biology · 2021Article
- A Rab escort protein regulates the MAPK pathway that controls filamentous growth in yeast.Scientific reports · 2020Article
- Salt-induced expression of intracellular vesicle trafficking genes, CaRab-GTP, and their association with NaBMC plant biology · 2020Article
- A Non-Canonical Calmodulin Target Motif Comprising a Polybasic Region and Lipidated Terminal Residue Regulates Localization.International journal of molecular sciences · 2020Review
- Intracellular Vesicle Trafficking Genes,Frontiers in genetics · 2019Article
- MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.Experimental eye research · 2015Article
- Vesicle trafficking from a lipid perspective: Lipid regulation of exocytosis in Saccharomyces cerevisiae.Cellular logistics · 2012Article
- Rab3D regulates amylase levels, not agonist-induced amylase release, in AR42J cells.Cellular & molecular biology letters · 2012Article
- Role of Rab GTPases in membrane traffic and cell physiology.Physiological reviews · 2011Review
- A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis.Genes & development · 2009Article
- Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation.The Journal of biological chemistry · 2009Article
- Hsp90 Co-localizes with Rab-GDI-1 and regulates agonist-induced amylase release in AR42J cells.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2009Article
- Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.The EMBO journal · 2008Article
- The Hsp90 chaperone complex regulates GDI-dependent Rab recycling.Molecular biology of the cell · 2006Article
- Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling.The EMBO journal · 2006Article
- Rab11 GTPase-regulated membrane trafficking is crucial for tip-focused pollen tube growth in tobacco.The Plant cell · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Prenylation of Rab GTPases regulating vesicle traffic by Rab geranylgeranyltransferase (RabGGTase) requires a complex formed by the association of newly synthesized Rab proteins with Rab-escort-protein (REP), the choroideremia-gene-product that is mutated in disease, leading to loss of vision. After delivery to the membrane by the REP-Rab complex, subsequent recycling to the cytosol requires the REP-related guanine-nucleotide-dissociation-inhibitor (GDI). Although REP and GDI share common Rab-binding properties, GDI cannot assist in Rab prenylation and REP cannot retrieve Rab proteins from the membranes. We have now isolated REP mutant proteins that are able to partially function as both REP and GDI. These results provide molecular insight into the functional and evolutionary organization of the REP/GDI superfamily.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.