ArticleMolecular biology of the cell2003
Role for Arf3p in development of polarity, but not endocytosis, in Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Role of Arf GTPases in fungal morphogenesis and virulence.PLoS pathogens · 2017Article
- Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain.Nature communications · 2015Article
- Arf3p GTPase is a key regulator of Bud2p activation for invasive growth in Saccharomyces cerevisiae.Molecular biology of the cell · 2013Article
- The endocytic adaptor proteins of pathogenic fungi: charting new and familiar pathways.Medical mycology · 2011Review
- ARF family G proteins and their regulators: roles in membrane transport, development and disease.Nature reviews. Molecular cell biology · 2011Review
- Endocytosis unplugged: multiple ways to enter the cell.Cell research · 2010Review
- FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Aspergillus nidulans ArfB plays a role in endocytosis and polarized growth.Eukaryotic cell · 2008Article
- Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis.Traffic (Copenhagen, Denmark) · 2008Article
- Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6.PloS one · 2007Article
- Trypanosoma brucei ARF1 plays a central role in endocytosis and golgi-lysosome trafficking.Molecular biology of the cell · 2007Article
- The Arf-GTPase-activating protein Gcs1p is essential for sporulation and regulates the phospholipase D Spo14p.Eukaryotic cell · 2006Article
- Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments.Molecular biology of the cell · 2005Article
- Lsb5p interacts with actin regulators Sla1p and Las17p, ubiquitin and Arf3p to couple actin dynamics to membrane trafficking processes.The Biochemical journal · 2005Article
- The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi.The Journal of cell biology · 2004Article
- Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers.Molecular biology of the cell · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ADP-ribosylation factors (ARFs) are ubiquitous regulators of virtually every step of vesicular membrane traffic. Yeast Arf3p, which is most similar to mammalian ARF6, is not essential for cell viability and not required for endoplasmic reticulum-to-Golgi protein transport. Although mammalian ARF6 has been implicated in the regulation of early endocytic transport, we found that Arf3p was not required for fluid-phase, membrane internalization, or mating-type receptor-mediated endocytosis. Arf3p was partially localized to the cell periphery, but was not detected on endocytic structures. The nucleotide-binding, N-terminal region, and N-terminal myristate of Arf3p are important for its proper localization. C-Terminally green fluorescent protein-tagged Arf3, expressed from the endogenous promoter, exhibited a polarized localization to the cell periphery and buds, in a cell cycle-dependent manner. Arf3-GFP achieved its proper localization during polarity growth through an actin-independent pathway. Both haploid and homologous diploid arf3 mutants exhibit a random budding defect, and the overexpression of the GTP-bound form Arf3p(Q71L) or GDP-binding defective Arf3p(T31N) mutant interfered with budding-site selection. We conclude that the GTPase cycle of Arf3p is likely to be important for the function of Arf3p in polarizing growth of the emerging bud and/or an unidentified vesicular trafficking pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.