ArticleMolecular biology of the cell2003
Expression of phosphatidylinositol (4,5) bisphosphate-specific pleckstrin homology domains alters direction but not the level of axonal transport of mitochondria.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 77 citations in OpenAlex.
- Article
- Structural and functional diversity of mitochondria in vestibular/cochlear hair cells and vestibular calyx afferents.Hearing research · 2022Review
- The Divergent Roles of Dietary Saturated and Monounsaturated Fatty Acids on Nerve Function in Murine Models of Obesity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Chain length of saturated fatty acids regulates mitochondrial trafficking and function in sensory neurons.Journal of lipid research · 2019Article
- Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- The Essentiality of Arachidonic Acid in Infant Development.Nutrients · 2016Review
- ClusTrack: feature extraction and similarity measures for clustering of genome-wide data sets.PloS one · 2015Article
- The role of phosphoinositides in synapse function.Molecular neurobiology · 2014Review
- Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.Open biology · 2013Article
- A steep phosphoinositide bis-phosphate gradient forms during fungal filamentous growth.The Journal of cell biology · 2012Article
- Axonal transport deficit in a KIF5A( -/- ) mouse model.Neurogenetics · 2012Article
- VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.Human molecular genetics · 2012Article
- Bidirectional intracellular transport: utility and mechanism.Biochemical Society transactions · 2011Article
- Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease.Journal of anatomy · 2011Review
- Vimentin intermediate filaments modulate the motility of mitochondria.Molecular biology of the cell · 2011Article
- Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Analysis of mitochondrial dynamics and functions using imaging approaches.Current protocols in cell biology · 2010Article
- Lipid signaling on the mitochondrial surface.Biochimica et biophysica acta · 2009Review
- Mitochondrial transport and docking in axons.Experimental neurology · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Axonal transport of membranous organelles such as mitochondria is essential for neuron viability and function. How signaling mechanisms regulate or influence mitochondrial distribution and transport is still largely unknown. We observed an increase in the distal distribution of mitochondria in neurons upon the expression of pleckstrin homology (PH) domains of phospholipase Cdelta1 (PLCdelta-PH) and spectrin (spectrin-PH). Quantitative analysis of mitochondrial transport showed that specific binding of PH domains to phosphatidylinositol (4,5) bisphosphate (PtdIns(4,5)P2) but not 3' phosphorylated phosphatidylinositol species enhanced plus-end-directed transport of mitochondria two- to threefold and at the same time decreased minus-end-directed transport of mitochondria along axonal microtubules (MTs) without altering the overall level of motility. Further, the velocity and duration of mitochondrial transport plus the association of molecular motors with mitochondria remained unchanged by the expression of PH domains. Thus, PtdIns(4,5)P2-specific PH domains caused an increase in distal mitochondria by disturbing the balance of plus- and minus-end-directed transport rather than directly affecting the molecular machinery involved. Taken together our data reveal that level and directionality of transport are separable and that PtdIns(4,5)P2 has a novel role in regulation of the directionality of axonal transport of mitochondria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.