ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2003
A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 121 citations in OpenAlex.
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- Snake venom gene expression is coordinated by novel regulatory architecture and the integration of multiple co-opted vertebrate pathways.Genome research · 2022Article
- Switching of vascular cells towards atherogenesis, and other factors contributing to atherosclerosis: a systematic review.Thrombosis journal · 2020Article
- The interdependence of gene-regulatory elements and the 3D genome.The Journal of cell biology · 2019Review
- Chromosome positioning and male infertility: it comes with the territory.Journal of assisted reproduction and genetics · 2018Review
- Cell-Specific PEAR1 Methylation Studies Reveal a Locus that Coordinates Expression of Multiple Genes.International journal of molecular sciences · 2018Article
- Article
- Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Chromosome intermingling-the physical basis of chromosome organization in differentiated cells.Nucleic acids research · 2016Article
- Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool.Frontiers in genetics · 2016Review
- The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms.Current topics in developmental biology · 2016Review
- The role of epigenetics in the endothelial cell shear stress response and atherosclerosis.The international journal of biochemistry & cell biology · 2015Review
- Review
- Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2015Review
- Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points.Experimental hematology · 2014Review
- Genome organization and long-range regulation of gene expression by enhancers.Current opinion in cell biology · 2013Review
- Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression.Molecular and cellular biology · 2013Article
- Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.Genome biology · 2013Article
- Something silent this way forms: the functional organization of the repressive nuclear compartment.Annual review of cell and developmental biology · 2013Review
- Differential DNA methylation patterns define status epilepticus and epileptic tolerance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies of nuclear organization have shown an apparent correlation between the localization of genes within the interphase nucleus and their transcriptional status. In several instances, actively transcribed gene loci have been found significantly looped away from their respective chromosome territories (CTs), presumably as a result of their expression. Here, we show evidence that extrusion of a gene locus from a CT by itself is not necessarily indicative of transcriptional activity, but also can reflect a poised state for activation. We found the murine and a wild-type human beta-globin locus looped away from their CTs at a high frequency only in a proerythroblast cell background, prior to the activation of globin transcription. Conversely, a mutant allele lacking the locus control region (LCR), which is required for high-level globin expression, was mostly coincident with the CT. The LCR may thus be responsible for the localization of the globin locus prior to activation. Replacement of the LCR with a B-cell-specific regulatory element, while also extruding the globin locus, brought it closer to the repressive centromeric heterochromatin compartment. We therefore suggest that the looping of gene loci from their CTs may reflect poised and repressed states, as well as the previously documented transcriptionally active state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.