Trial reportWorld journal of gastroenterology2003
Clinical study on nutrition support in patients with severe acute pancreatitis.
Trial report in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Nasogastric versus nasojejunal tube feeding for severe acute pancreatitis.The Cochrane database of systematic reviews · 2020Pooled it
- Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee.Journal of pediatric gastroenterology and nutrition · 2018Guideline
- Enteral nutrition in acute pancreatitis: a review of the current evidence.World journal of gastroenterology · 2014Pooled it
- Evidence-based use of enteral nutrition in acute pancreatitis.Langenbeck's archives of surgery · 2010Pooled it
- Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis.BMJ (Clinical research ed.) · 2004Pooled it
- Effects of different resuscitation fluid on severe acute pancreatitis.World journal of gastroenterology · 2013Trial
- Translational Pharmaco-Nutritional Approaches in the Management of Clinical Acute Pancreatitis-A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Fire in the belly: A scoping review of the immunopathological mechanisms of acute pancreatitis.Frontiers in immunology · 2022Article
- Management of infected pancreatic necrosis in the setting of concomitant rectal cancer: A case report and review of literature.World journal of gastrointestinal surgery · 2019Article
- Gastroenterology - Guidelines on Parenteral Nutrition, Chapter 15.German medical science : GMS e-journal · 2009Review
- Early enteral nutrition in acute pancreatitis--benefits and limitations.Langenbeck's archives of surgery · 2008Review
- Acute pancreatitis--from cellular signalling to complicated clinical course.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2007Article
- Current management of acute pancreatitis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2005Review
- What is New in Acute Pancreatitis?Medical journal, Armed Forces India · 2005Article
- Clinical characteristics and management of patients with early acute severe pancreatitis: experience from a medical center in China.World journal of gastroenterology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of nutritional support therapy on severe acute pancreatitis (SAP).
methodsA total of 96 patients with severe acute pancreatitis were divided randomly into control and treatment groups. The former group received total parenteral nutrition (TPN) via central venous infusion, while parenteral nutrition (PN) and enteral nutrition (EN) therapies were applied in different phases for the latter group. The nutrition status, acute phase responses, pancreas lesions, enteric mucosa penetrability and immune functions were monitored.
resultsBody weight and prealbumin concentration were increased in treatment group, compared to those in the control group, but albumin concentration did not change significantly. Acute physiology and chronic health evaluation II (APACHE II) scores decreased after 7 d of treatment, whereas the scores of the control group decreased on the 11(th) day. Concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukine-6 (IL-6) and serum C reactive protein (CRP) dropped earlier in the treatment group (on the 4(th) day) than that in the control group (on the 7(th) day). No difference was observed in pancreatic lesions between the control and treatment groups. Concentration of endotoxin and lactulose/manicol (L:M) ratio of urine did not change in treatment group, but those in the control group were elevated markedly. Compared with the treatment group, CD4:CD8 T cells ratio and immunoglobulin G (IgG) concentration in the control group decreased significantly.
conclusionCompared to TPN, the combined therapy of EN and PN could improve the nutrition status and moderate the acute phase response obviously. Moreover, the integrity of enteric mucosa and immune function were protected more effectively in treatment group than in the control one. On the other hand, EN did not simulate the excretion of pancreas and avoid exaggerating the inflammation of pancreas. Thus, appropriate application of PN and EN appears to be more effective for patients with SAP.
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