ArticleWorld journal of gastroenterology2003
Clinical effects of continuous high volume hemofiltration on severe acute pancreatitis complicated with multiple organ dysfunction syndrome.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Fever on hospital admission is associated with increased disease severity and mortality in acute pancreatitis: a systematic review and meta-analysis.Systematic reviews · 2026Pooled it
- Effect of Early Continuous Veno-Venous Haemofiltration in Severe Acute Pancreatitis for the Prevention of Local Pancreatic Complications.Gastroenterology research and practice · 2022Article
- Hemofiltration in Patients with Severe Acute Pancreatitis (Review).Sovremennye tekhnologii v meditsine · 2020Review
- Hemoperfusion plus continuous veno-venous hemofiltration in a pregnant woman with severe acute pancreatitis: a case report.International urology and nephrology · 2012Article
- Effects of high-volume hemofiltration on alveolar-arterial oxygen exchange in patients with refractory septic shock.World journal of emergency medicine · 2011Article
- Clinical effects of laparotomy with perioperative continuous peritoneal lavage and postoperative hemofiltration in patients with severe acute pancreatitis.World journal of emergency surgery : WJES · 2009Article
- Continuous veno-venous haemofiltration in the treatment of severe acute pancreatitis: 6-year experience.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2007Article
- Increased intra-abdominal pressure: is it of any consequence in severe acute pancreatitis?HPB : the official journal of the International Hepato Pancreato Biliary Association · 2006Article
- Amelioration of hemodynamics and oxygen metabolism by continuous venovenous hemofiltration in experimental porcine pancreatitis.World journal of gastroenterology · 2005Article
- Clinical characteristics and management of patients with early acute severe pancreatitis: experience from a medical center in China.World journal of gastroenterology · 2004Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the efficiency of continuous high volume hemofiltration (HVHF) in the treatment of severe acute pancreatitis (SAP) complicated with multiple organ dysfunction syndrome (MODS).
methodsA total of 28 SAP patients with an average of 14.36+/-3.96 APACHE II score were involved. Diagnostic criteria for SAP standardized by the Chinese Medical Association and diagnostic criteria for MODS standardized by American College of Chest Physicians (ACCP) and Society of Critical Care Medicine (SCCM) were applied for inclusion. HVHF was started 6.0+/-6.1 (1-30) days after onset of the disease and sustained for at least 72 hours, AN69 hemofilter (1.2 m(2)) was changed every 24 hours. The ultrafiltration rate during HVHF was 4 000 ml/h, blood flow rate was 250-300 ml/min, and the substitute fluid was infused with pre-dilution. Low molecular weight heparin was used for anticoagulation.
resultsHVHF was well tolerated in all the patients, and lasted for 4.04+/-3.99 (3-24) days. 20 of the patients survived, 6 patients died and 2 of the patients quited for financial reason. The ICU mortality was 21.4 %. Body temperature, heart rate and breath rate decreased significantly after HVHF. APACHE II score was 14.4+/-3.9 before HVHF, and 9.9+/-4.3 after HVHF, which decreased significantly (P<0.01). Partial pressure of oxygen in arterial blood before HVHF was 68.5+/-19.5 mmHg, and increased significantly after HVHF, which was 91.9+/-25 mmHg (P<0.01). During HVHF the hemodynamics was stable, and serum potassium, sodium, chlorine, glucose and pH were at normal level.
conclusionHVHF is technically possible in SAP patients complicated with MODS. It does not appear to have detrimental effects and may have beneficial effects. Continuous HVHF, which seldom disturbs the hemodynamics and causes few side-effects, is expected to become a beneficial adjunct therapy for SAP complicated with MODS.
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