ArticleWorld journal of gastroenterology2003
Detection of T lymphocyte subsets and mIL-2R on surface of PBMC in patients with hepatitis B.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Effect of liniment levamisole on cellular immune functions of patients with chronic hepatitis B.World journal of gastroenterology · 2005Trial
- Effect of Hejie decoction on T cell immune state of chronic hepatitis B patients.World journal of gastroenterology · 2004Trial
- Expression of CD11b and CD18 on polymorphonuclear neutrophils stimulated with interleukin-2.Central-European journal of immunology · 2014Article
- Relationship between serum HBsAg level, HBV DNA level, and peripheral immune cells in patients with chronic hepatitis B virus infection.Hepatic medicine : evidence and research · 2010Article
- Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests.World journal of gastroenterology · 2008Article
- Expression of T subsets and mIL-2R in peripheral blood of newborns with hypoxic ischemic encephalopathy.World journal of pediatrics : WJP · 2008Article
- Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B.World journal of gastroenterology · 2008Article
- Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population.World journal of gastroenterology · 2005Article
- HBV cccDNA in patients' sera as an indicator for HBV reactivation and an early signal of liver damage.World journal of gastroenterology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the levels of T lymphocyte subsets and membrane interleukin-2 receptor (mIL-2R) on surface of peripheral blood mononuclear cells (PBMCs) of patients with hepatitis B and its role in the pathogenesis of hepatitis B.
methodsThe levels of T lymphocyte subsets and mIL-2R in PBMC before and after being stimulated with PHA were detected by biotin-streptavidin (BSA) technique in 196 cases of hepatitis B.
resultsIn patients with hepatitis B, the levels of CD(3)(+), CD(4)(+) cells, and the ratio of CD(4)(+) cells/CD(8)(+) cells were lower, but the level of CD(8)(+) cells was higher than those in normal controls (42.20+/-6.01 vs 65.96+/-6.54, 38.17+/-5.93 vs 41.73+/-6.40, 0.91+/-0.28 vs 1.44+/-0.31, 39.86+/-6.36 vs 30.02+/-4.54, P<0.01). The total expression level of mIL-2R in PBMC before and after being stimulated with PHA was also lower than those in normal controls (3.47+/-1.55 vs 4.52+/-1.49, 34.03+/-2.94 vs 37.95+/-3.00, P<0.01). In all the patients with hepatitis B, the levels of T lymphocyte subsets and mIL-2R in PBMC with HBV-DNA (+) were lower than those with HBV-DNA (-), which were significantly different (39.57+/-7.11 vs 44.36+/-5.43, 34.36+/-7.16 vs 40.75+/-5.87, 37.82+/-6.54 vs 41.72+/-6.21, 0.88+/-0.33 vs 0.99+/-0.27, 2.82+/-1.62 vs 3.85+/-1.47, 31.56+/-3.00 vs 35.84+/-2.83, P<0.01). In addition, the levels of CD(3)(+), CD(4)(+), CD(8)(+) cells, the ratio of CD(4)(+) cells /CD(8)(+) cells and mIL-2R among different courses of hepatitis B were all significantly different (F=3 723.18, P<0.01. F=130.43, P<0.01. F=54.01, P<0.01. F=2.99, P<0.05. F=7.16, P<0.01).
conclusionBoth cellular and humoral immune functions are obviously in disorder in patients with hepatitis B, which might be closely associated with the chronicity in patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.