ArticleWorld journal of gastroenterology2003
Expression and significance of RhoC gene in hepatocellular carcinoma.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.Frontiers in oncology · 2021Article
- CircRhoC promotes tumorigenicity and progression in ovarian cancer by functioning as a miR-302e sponge to positively regulate VEGFA.Journal of cellular and molecular medicine · 2019Article
- RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target.Journal of experimental & clinical cancer research : CR · 2019Review
- Article
- Expression And Biological Interaction Network Of RHOC For Hepatic Carcinoma With Metastasis In PBMC Samples.OncoTargets and therapy · 2019Article
- Sorafenib induces variations of the DNA methylome in HA22T/VGH human hepatocellular carcinoma-derived cells.International journal of oncology · 2017Article
- Atorvastatin inhibits RhoC function and limits head and neck cancer metastasis.Oral oncology · 2013Article
- Overexpression of Ras homologous C (RhoC) induces malignant transformation of hepatocytes in vitro and in nude mouse xenografts.PloS one · 2013Article
- Inhibition of rho-kinase by fasudil suppresses formation and progression of experimental abdominal aortic aneurysms.PloS one · 2013Article
- Article
- The role of RhoC in the proliferation and apoptosis of hepatocellular carcinoma cells.Medical oncology (Northwood, London, England) · 2012Article
- The interaction of PKN3 with RhoC promotes malignant growth.Molecular oncology · 2012Article
- Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer.Toxicologic pathology · 2011Article
- Individual rac GTPases mediate aspects of prostate cancer cell and bone marrow endothelial cell interactions.Journal of signal transduction · 2011Article
- [Expressions and significances of PRL-3 and RhoC in A549 cell].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Article
- [Expression and its relationship of PRL-3 and RhoC in non-small cell lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Article
- Identification of gene expression profiling in hepatocellular carcinoma using cDNA microarrays.Digestive diseases and sciences · 2009Article
- The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer.Digestive diseases and sciences · 2008Article
- Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis.Clinical & experimental metastasis · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression of RhoC gene in hepatocellular carcinoma (HCC) and to evaluate the relationship between RhoC gene expression and invasion and metastasis of HCC.
methodsmRNA expression level of RhoC gene was examined by reverse transcription-polymerase chain reaction (RT-PCR) in 25 cases of HCC and para-cancerous normal liver tissues. In addition, mutation of RhoC gene was examined by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP).
resultsThe mRNA expression levels of RhoC in tumor tissues were significantly higher than those in para-cancerous normal liver tissues (1.8+/-1.1 vs 1.0+/-0.7, P<0.01). The metastatic lesions outside of liver also showed significantly higher RhoC mRNA levels than corresponding tumor tissues in liver (3.3+/-0.5 vs 2.0+/-0.7, P<0.01). There were significant associations between RhoC gene expression and certain clinical and pathological findings, including cell differentiation, vein invasion, number of tumor nodes and metastatic lesions. Mutation of RhoC gene was not found by PCR-SSCP.
conclusionThe RhoC gene may be related to malignant transformation and development of HCC and may play an important role in the invasion and metastasis of HCC by overexpression but not mutation.
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