ArticleWorld journal of gastroenterology2003
Pathomorphological study on location and distribution of Kupffer cells in hepatocellular carcinoma.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
- Safety and pharmacokinetics of the antisense oligonucleotide (ASO) LY2181308 as a single-agent or in combination with idarubicin and cytarabine in patients with refractory or relapsed acute myeloid leukemia (AML).Investigational new drugs · 2013Trial
- Sonazoid-contrast-enhanced ultrasound for the histological diagnosis of hepatocellular carcinoma.World journal of gastrointestinal oncology · 2026Article
- Kupffer phase echo level ratio in contrast-enhanced ultrasound for differentiating malignant liver tumors.Quantitative imaging in medicine and surgery · 2025Article
- MRI proton density fat fraction for estimation of biological characteristics in hepatocellular carcinoma.BMC medical imaging · 2025Article
- Intra-individual comparison of Sonazoid contrast-enhanced ultrasound and SonoVue contrast-enhanced ultrasound in diagnosing hepatocellular carcinoma.Abdominal radiology (New York) · 2024Article
- Therapeutic Potential of Targeting Prokineticin Receptors in Diseases.Pharmacological reviews · 2023Review
- Contrast-Enhanced Imaging Features and Clinicopathological Investigation of Steatohepatitic Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2023Article
- Current tests for diagnosis of hepatitis B virus infection and immune responses of HBV-related HCC.Frontiers in oncology · 2023Review
- Head-to-head comparison of Sonazoid and SonoVue in the diagnosis of hepatocellular carcinoma for patients at high risk.Frontiers in oncology · 2023Article
- Article
- Comparison of Sonazoid contrast-enhanced ultrasound and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid MRI for the histological diagnosis of hepatocellular carcinoma.Quantitative imaging in medicine and surgery · 2021Article
- Emerging role of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma.Medicina (Kaunas, Lithuania) · 2019Review
- Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions.Scientific reports · 2017Article
- Macrophage colony-stimulating factor expressed in non-cancer tissues provides predictive powers for recurrence in hepatocellular carcinoma.World journal of gastroenterology · 2016Article
- Effect of CD16a, the surface receptor of Kupffer cells, on the growth of hepatocellular carcinoma cells.International journal of molecular medicine · 2016Article
- Advances in computed tomography and magnetic resonance imaging of hepatocellular carcinoma.World journal of gastroenterology · 2016Review
- Blockade of the apelin-APJ system promotes mouse liver regeneration by activating Kupffer cells after partial hepatectomy.Journal of gastroenterology · 2015Article
- Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.Journal of molecular histology · 2015Article
- Beneficial effects of green tea catechin on massive hepatectomy model in rats.Journal of gastroenterology · 2014Article
- Quantitative liver lesion volume determination by nanoparticle-based SPECT.Molecular imaging and biology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo clarify the location and distribution of Kupffer cells in hepatocellular carcinoma (HCC), and to investigate their role in hepatocarcinogenesis.
methodsKupffer cells were immunohistochemically stained by streptavadin-peroxidase conjugated method (S-P). The numbers of Kupffer cells in cancerous, para-cancerous and adjacent normal liver tissues of 48 HCCs were comparatively examined.
resultsThe mean number of Kupffer cells in cancerous, para-cancerous and adjacent normal liver tissues was 12.7+/-6.8, 18.1+/-8.2 and 18.9+/-7.9 respectively. The number of Kuppfer cells in cancerous tissues was significantly lower than that in para-cancerous tissues (t=2.423, P<0.05) and adjacent normal liver tissues (t=2.521, P<0.05). As tumor size increased, the number of Kupffer cells in cancerous tissues significantly decreased (F=4.61, P<0.05). Moreover, there was also a significant difference in the number of Kupffer cells among well-differentiated, moderately-differentiated and poorly-differentiated cases(F=4.49, P<0.05).
conclusionThis study suggests that decrease of Kupffer cells in HCCs may play an important role in the carcinogenesis of HCC, the number of Kupffer cells in HCC is closely related to the size and differentiation grade of the tumor.
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