Gene silencing of the p15/INK4B cell-cycle inhibitor by hypermethylation: an early or later epigenetic alteration in myelodysplastic syndromes?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

1. Realgar (α-AsChinese journal of integrative medicine · 2022
   Review
2. A study on DNA methylation status in promoter region of p15 gene in patients of acute myeloid leukemia and myelodysplastic syndrome.Medical journal, Armed Forces India · 2021
   Article
3. Mutations in histone modulators are associated with prolonged survival during azacitidine therapy.Oncotarget · 2016
   Article
4. Quantitative Detection of ID4 Gene Aberrant Methylation in the Differentiation of Myelodysplastic Syndrome from Aplastic Anemia.Chinese medical journal · 2015
   Article
5. Downregulation of HO-1 promoted apoptosis induced by decitabine via increasing p15INK4B promoter demethylation in myelodysplastic syndrome.Gene therapy · 2015
   Article
6. The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO.Oncogene · 2011
   Article
7. Development of an oral form of azacytidine: 2'3'5'triacetyl-5-azacytidine.Chemotherapy research and practice · 2011
   Article
8. The long arm of long noncoding RNAs: roles as sensors regulating gene transcriptional programs.Cold Spring Harbor perspectives in biology · 2011
   Review
9. Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA.Nature · 2008
   Article
10. Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias.Current medicinal chemistry · 2008
    Review
11. Lenalidomide: a brief review of its therapeutic potential in myelodysplastic syndromes.Therapeutics and clinical risk management · 2007
    Article
12. DNA methylation as a therapeutic target in hematologic disorders: recent results in older patients with myelodysplasia and acute myeloid leukemia.International journal of hematology · 2004
    Review
13. From bacteria to humans, chromatin to elongation, and activation to repression: The expanding roles of noncoding RNAs in regulating transcription.Critical reviews in biochemistry and molecular biology
    Review

Corrections and comments

• Comment on
  Expression levels of DNA methyltransferase genes do not correlate with p15INK4B gene methylation in myelodysplastic syndromes.2003

Authors and funding

1 author at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as