ArticleJournal of virology2003
Tissue-specific replicating capacity of a chimeric poliovirus that carries the internal ribosome entry site of hepatitis C virus in a new mouse model transgenic for the human poliovirus receptor.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- IRES-Mediated Translation: Expanding the Toolkits of RNA Therapy.International journal of molecular sciences · 2025Review
- CNS Viral Infections-What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches.CNS drugs · 2024Review
- Review
- Enterovirus and Encephalitis.Frontiers in microbiology · 2020Review
- Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation.The Journal of general virology · 2014Article
- Specific interaction of the envelope glycoproteins E1 and E2 with liver heparan sulfate involved in the tissue tropismatic infection by hepatitis C virus.Glycoconjugate journal · 2012Article
- Translation initiation of viral mRNAs.Reviews in medical virology · 2010Review
- Innate host barriers to viral trafficking and population diversity: lessons learned from poliovirus.Advances in virus research · 2010Review
- Attenuation of rabies virus replication and virulence by picornavirus internal ribosome entry site elements.Journal of virology · 2009Article
- Molecular aspects of poliovirus pathogenesis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2007Review
- Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor.Journal of virology · 2007Article
- Role of the alpha/beta interferon response in the acquisition of susceptibility to poliovirus by kidney cells in culture.Journal of virology · 2006Article
- Age-dependent poliovirus replication in the mouse central nervous system is determined by internal ribosome entry site-mediated translation.Journal of virology · 2006Article
- The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus.Journal of virology · 2005Article
- Molecular mechanisms of attenuation of the Sabin strain of poliovirus type 3.Journal of virology · 2004Article
- Poliovirus tropism and attenuation are determined after internal ribosome entry.The Journal of clinical investigation · 2004Article
- Poliovirus proves IRES-istible in vivo.The Journal of clinical investigation · 2004Article
- Replication of poliovirus RNA with complete internal ribosome entry site deletions.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleotides (nt) 108 to 742 of an infectious cDNA clone of poliovirus (PV) Mahoney strain, including the corresponding region of the internal ribosome entry site (IRES), was replaced by nt 28 to 710 of hepatitis C virus (HCV) cDNA corresponding to the whole HCV IRES. A chimeric PV (2A-369) was generated by transfecting mammalian cells with an RNA transcribed in vitro from the cDNA. To examine replicating capacity of virus 2A-369 in the brain and liver of a mouse model for poliomyelitis, a new mouse model (MPVRTg25-61) that is transgenic for human PV receptor (hPVR; CD155) was generated in order to obtain a higher expression level of hPVR in the liver than those of hPVRTg mouse lines generated by us so far. The transgene used was constructed by combining a putative regulatory region of the mouse PVR homolog and the whole structural region of the hPVR gene. Virus 2A-369 replicated well in the liver of MPVRTg25-61 but not in the brain, whereas control Mahoney virus replicated well both in the liver and in the brain. The data suggest that the HCV IRES works more efficiently in the liver than in the brain and that PV IRES works well both in the liver and in the brain. The results support the notion that tissue-specific activity of IRES may be reflected in tissue tropism of a virus whose specific translation initiation is driven by IRES, that is, an IRES-dependent virus tropism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.