ArticleJournal of virology2003
Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 147 citations in OpenAlex.
- Article
- New Safety Aspects in Corneal Donation-Studies on SARS-CoV-2-Positive Corneal Donors.Journal of clinical medicine · 2022Article
- miR-30d Inhibition Protects IPEC-J2 Cells AgainstFrontiers in veterinary science · 2022Article
- PA28γ-20S proteasome is a proteolytic complex committed to degrade unfolded proteins.Cellular and molecular life sciences : CMLS · 2021Article
- PA28γ: New Insights on an Ancient Proteasome Activator.Biomolecules · 2021Review
- Race to arsenal COVID-19 therapeutics: Current alarming status and future directions.Chemico-biological interactions · 2020Review
- Proteasome activator PA28γ-dependent degradation of coronavirus disease (COVID-19) nucleocapsid protein.Biochemical and biophysical research communications · 2020Article
- PA28γ, an Accomplice to Malignant Cancer.Frontiers in oncology · 2020Review
- Visfatin serum concentration and hepatic mRNA expression in chronic hepatitis C.Clinical and experimental hepatology · 2019Article
- Proteasomes and Several Aspects of Their Heterogeneity Relevant to Cancer.Frontiers in oncology · 2019Review
- Specific Modification of Aged Proteasomes Revealed by Tag-Exchangeable Knock-In Mice.Molecular and cellular biology · 2019Article
- HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expression.Journal of molecular medicine (Berlin, Germany) · 2017Article
- TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.Nature communications · 2016Article
- Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility.Scientific reports · 2016Article
- The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens.Cell reports · 2016Article
- Gates, Channels, and Switches: Elements of the Proteasome Machine.Trends in biochemical sciences · 2016Review
- Involvement of FKBP6 in hepatitis C virus replication.Scientific reports · 2015Article
- Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression.Scientific reports · 2015Article
- Proteomic approaches to analyzing hepatitis C virus biology.Proteomics · 2015Review
- Hepatitis C virus and host cell nuclear transport machinery: a clandestine affair.Frontiers in microbiology · 2015Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) core protein plays an important role in the formation of the viral nucleocapsid and a regulatory protein involved in hepatocarcinogenesis. In this study, we have identified proteasome activator PA28gamma (11S regulator gamma) as an HCV core binding protein by using yeast two-hybrid system. This interaction was demonstrated not only in cell culture but also in the livers of HCV core transgenic mice. These findings are extended to human HCV infection by the observation of this interaction in liver specimens from a patient with chronic HCV infection. Neither the interaction of HCV core protein with other PA28 subtypes nor that of PA28gamma with other Flavivirus core proteins was detected. Deletion of the PA28gamma-binding region from the HCV core protein or knockout of the PA28gamma gene led to the export of the HCV core protein from the nucleus to the cytoplasm. Overexpression of PA28gamma enhanced the proteolysis of the HCV core protein. Thus, the nuclear retention and stability of the HCV core protein is regulated via a PA28gamma-dependent pathway through which HCV pathogenesis may be exerted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.