ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Modulation of synaptic transmission by the BCL-2 family protein BCL-xL.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 100 citations in OpenAlex.
- The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo.Scientific reports · 2025Article
- Anthocyanins Promote Learning through Modulation of Synaptic Plasticity Related Proteins in an Animal Model of Ageing.Antioxidants (Basel, Switzerland) · 2021Article
- The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism.Nature metabolism · 2020Article
- ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration.Journal of molecular and cellular cardiology · 2020Review
- Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.Neurochemistry international · 2017Review
- Physiological roles of the mitochondrial permeability transition pore.Journal of bioenergetics and biomembranes · 2017Review
- Anti-inflammatory, antiapoptotic, and antioxidant activity of fluoxetine.Pharmacology research & perspectives · 2016Review
- Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase.Pharmacological research · 2015Review
- Contributions of Bcl-xL to acute and long term changes in bioenergetics during neuronal plasticity.Biochimica et biophysica acta · 2014Review
- Bcl-xL in neuroprotection and plasticity.Frontiers in physiology · 2014Review
- A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.Nature cell biology · 2013Article
- Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease.Neurobiology of disease · 2013Review
- Multiple functions of BCL-2 family proteins.Cold Spring Harbor perspectives in biology · 2013Review
- Contribution of apoptosis-associated signaling pathways to epileptogenesis: lessons from Bcl-2 family knockouts.Frontiers in cellular neuroscience · 2013Article
- Prolonged expression of Puma in cholinergic amacrine cells during the development of rat retina.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.Nature neuroscience · 2012Article
- Caspase-3 activation is required for reovirus-induced encephalitis in vivo.Journal of neurovirology · 2010Article
- Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease.Frontiers in synaptic neuroscience · 2010Article
- Gene expression profiling reveals distinct cocaine-responsive genes in human fetal CNS cell types.Journal of addiction medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
BCL-2 family proteins are known to regulate cell death during development by influencing the permeability of mitochondrial membranes. The anti-apoptotic BCL-2 family protein BCL-xL is highly expressed in the adult brain and localizes to mitochondria in the presynaptic terminal of the adult squid stellate ganglion. Application of recombinant BCL-xL through a patch pipette to mitochondria inside the giant presynaptic terminal triggered multiconductance channel activity in mitochondrial membranes. Furthermore, injection of full-length BCL-xL protein into the presynaptic terminal enhanced postsynaptic responses and enhanced the rate of recovery from synaptic depression, whereas a recombinant pro-apoptotic cleavage product of BCL-xL attenuated postsynaptic responses. The effect of BCL-xL on synaptic responses persisted in the presence of a blocker of mitochondrial calcium uptake and was mimicked by injection of ATP into the terminal. These studies indicate that the permeability of outer mitochondrial membranes influences synaptic transmission, and they raise the possibility that modulation of mitochondrial conductance by BCL-2 family proteins affects synaptic stability.
Indexed as
Identifiers
12968005PMC6740692W2165983675What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.