ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 65 citations in OpenAlex.
- Engineering of a wireless single capacitive discharge conductivity-clamped gene electrotransfer probe for naked nucleic acid therapeutics.APL bioengineering · 2026Article
- Functional consequences of calmodulin variants identified among schizophrenia patients and controls.Translational psychiatry · 2025Article
- Gene Electrotransfer via Conductivity-Clamped Electric Field Focusing Pivots Sensori-Motor DNA Therapeutics: "A Spoonful of Sugar Helps the Medicine Go Down".Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The Pathway-Selective Dependence of Nitric Oxide for Long-Term Potentiation in the Anterior Cingulate Cortex of Adult Mice.Biomedicines · 2024Article
- Optimization of a Pyrimidinone Series for Selective Inhibition of CaJournal of medicinal chemistry · 2022Article
- NMDA Receptor Dependent Long-term Potentiation in Chronic Pain.Neurochemical research · 2019Review
- Direct visualization of interaction between calmodulin and connexin45.The Biochemical journal · 2017Article
- Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain.Nature reviews. Neuroscience · 2016Review
- In vivo rapid gene delivery into postmitotic neocortical neurons using iontoporation.Nature protocols · 2015Article
- Calmodulin regulation (calmodulation) of voltage-gated calcium channels.The Journal of general physiology · 2014Review
- Long-term potentiation in the anterior cingulate cortex and chronic pain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- First knockdown gene expression in bat (Hipposideros armiger) brain mediated by lentivirus.Molecular biotechnology · 2013Article
- Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation.Neural development · 2012Article
- Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain.Journal of molecular medicine (Berlin, Germany) · 2011Review
- Inhibition of gastric motility by hyperglycemia is mediated by nodose ganglia KATP channels.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Interplay of amygdala and cingulate plasticity in emotional fear.Neural plasticity · 2011Review
- Single neuron electroporation in manipulating and measuring the central nervous system.International archives of medicine · 2010Article
- In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice.Molecular pain · 2010Article
- Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
We developed a microelectroporation method for the transfer of genes into neurons in the cerebral cortex of adult rodents, both rats and mice. We selectively expressed either green-fluorescent protein (GFP) or a Ca2+-binding deficient calmodulin (CaM) mutant in the anterior cingulate cortex (ACC). In mice that expressed GFP, positive neuronal cell bodies were found specifically at the injection site in the ACC. Mice that expressed CaM12, a mutant CaM with two impaired Ca2+ binding sites in the N-terminal lobe, exhibited significant changes in vocalization, locomotion, and sensory functions. Long-term potentiation and long-term depression, two major forms of central plasticity, were completely abolished by expression of CaM12. Mice that expressed CaM34, a mutant CaM with two impaired Ca2+ binding sites in the C-terminal lobe, did not show any significant behavioral or electrophysiological alterations. These findings provide strong evidence that CaM is critical for bidirectional synaptic plasticity. This new method will be useful for investigating gene function in specific brain regions of freely moving animals. Furthermore, this approach also may facilitate gene therapy in adult human brains.
Indexed as
Identifiers
12968002PMC6740679W1858253487What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.