ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Burst-induced synaptic depression and its modulation contribute to information transfer at Aplysia sensorimotor synapses: empirical and computational analyses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Repeated stimulation of feeding mechanoafferents inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Differential Excitability of PV and SST Neurons Results in Distinct Functional Roles in Inhibition Stabilization of Up States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Burst-induced anti-Hebbian depression acts through short-term synaptic dynamics to cancel redundant sensory signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Short-Term Plasticity in a Computational Model of the Tail-Withdrawal Circuit in Aplysia.Neurocomputing · 2007Article
- Long-term sensitization training produces spike narrowing in Aplysia sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Variability of motor neuron spike timing maintains and shapes contractions of the accessory radula closer muscle of Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- The action of spike frequency adaptation in the postural motoneurons of hermit crab abdomen during the first phase of reflex activation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Article
- Mechanosensory S-neurons rather than AH-neurons appear to generate a rhythmic motor pattern in guinea-pig distal colon.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Aplysia sensorimotor synapse is a key site of plasticity for several simple forms of learning. Plasticity of this synapse has been extensively studied, albeit primarily with individual action potentials elicited at low frequencies. Yet, the mechanosensory neurons fire high-frequency bursts in response to even moderate tactile stimuli delivered to the skin. In the present study, we extend this analysis to show that sensory neurons also fire bursts in the range of 1-60 Hz in response to electrical stimuli similar to those used in behavioral studies of sensitization. Intracellular stimulation of sensory neurons to fire a burst of action potentials at 10 Hz for 1 sec led to significant homosynaptic depression of postsynaptic responses. The depression was transient and fully recovered within 10 min. During the burst, the steady-state depressed phase of the postsynaptic response, which was only 20% of the initial EPSP of the burst, still contributed to firing the motor neuron. To explore the functional contribution of transient homosynaptic depression to the response of the motor neuron, computer simulations of the sensorimotor synapse with and without depression were compared. Depression allowed the motor neuron to produce graded responses over a wide range of presynaptic input strength. In addition, enhancement of synaptic transmission throughout a burst increased motor neuron output substantially more than did preferential enhancement of the initial phase of a burst. Thus, synaptic depression increased the dynamic range of the sensorimotor synapse and can, in principle, have a profound effect on information processing.
Indexed as
Identifiers
12968001PMC6740707W1636577383What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.