ArticleBritish journal of pharmacology2003
Electrical properties of detrusor smooth muscles from the pig and human urinary bladder.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 103 citations in OpenAlex.
- Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle.The Journal of physiology · 2026Review
- Smooth muscle of the lower urinary tract: BK-RyR coupling in physiology and pathophysiology.Journal of muscle research and cell motility · 2025Review
- Biophysical Mechanisms of Vaginal Smooth Muscle Contraction: The Role of the Membrane Potential and Ion Channels.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- PTHrP attenuates spontaneous contractions in detrusor smooth muscle of the rat bladder by activating spontaneous transient outward potassium currents.Pflugers Archiv : European journal of physiology · 2024Article
- Inhibition of prejunctional parasympathetic pathways by βFrontiers in pharmacology · 2023Article
- Role of detrusor PDGFRαScientific reports · 2022Article
- Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype.Life sciences · 2022Article
- Urinary bladder smooth muscle ion channels: expression, function, and regulation in health and disease.American journal of physiology. Renal physiology · 2020Review
- Article
- A computational model of large conductance voltage and calcium activated potassium channels: implications for calcium dynamics and electrophysiology in detrusor smooth muscle cells.Journal of computational neuroscience · 2019Article
- Effect of high-fat diet-induced obesity on the small-conductance CaInternational urology and nephrology · 2019Article
- Nerve-induced responses of mouse vaginal smooth muscle.Pflugers Archiv : European journal of physiology · 2017Article
- Regulation of transient receptor potential melastatin 4 channel by sarcoplasmic reticulum inositol trisphosphate receptors: Role in human detrusor smooth muscle function.Channels (Austin, Tex.) · 2017Article
- Nongenomic modulation of the large conductance voltage- and CaPhysiological reports · 2017Article
- KNaunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Pharmacological methods for the preclinical assessment of therapeutics for OAB: an up-to-date review.International urogynecology journal · 2016Review
- Big-conductance CaChannels (Austin, Tex.) · 2016Review
- Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling.The Journal of general physiology · 2016Article
- Novel regulatory mechanism in human urinary bladder: central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function.American journal of physiology. Cell physiology · 2016Article
- 2014 Conway review lecture, Royal Academy of Medicine in Ireland: “S6, drugs and RCK and Bowl”.Irish journal of medical science · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) The electrophysiological properties of detrusor smooth muscles have been studied almost exclusively in small mammals and the relevance of the information to the human bladder has been questioned. In the present study, electrical properties of detrusor smooth muscles of the pig and human were investigated using intracellular recording techniques. (2) Bladder smooth muscles of the pig and human exhibited nifedipine (10 microm)-sensitive spontaneous action potentials, and their frequency was highly sensitive to membrane polarization. (3) During bursts of action potentials, each action potential was followed by a fast after-hyperpolarization (fast AHP). Charybdotoxin (CTX, 50 nm) increased the amplitude and duration of action potentials but failed to inhibit the fast AHPs, while apamin (0.1 microm) blocked the fast AHPs and induced action potential complexes, which were followed by slow AHPs. 4-Aminopyridine (4-AP, 1 mm) suppressed the slow AHP and increased action potential frequency. (4) In the human bladder, transmural stimuli initiated inhibitory junction potential-like hyperpolarizations, which were followed by action potential discharges. The hyperpolarizations were blocked by atropine (1 microm) and by apamin (0.1 microm) but not by CTX (50 nm). In the pig bladder, transmural stimuli evoked excitatory junction potentials (EJPs), which triggered action potentials. After desensitizing P2x receptors with alpha,beta methylene-ATP (10 microm), nerve-evoked responses were similar to those of human bladder. (5) These results indicate that detrusor smooth muscles of the pig share many features of electrical properties with those of the human. In addition to large conductance (BK) and small conductance (SK) Ca2+-activated K+ channels, voltage-dependent K+ (VK) channels may play an important role in the regulation of electrical activity of detrusor smooth muscles.
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