ArticleBritish journal of pharmacology2003
Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- Upregulated 5-HTJournal of neurotrauma · 2023Article
- Liposomal formulations of oxybutynin and resiniferatoxin for the treatment of urinary diseases: improvement of drug tolerance upon intravesical.Drug delivery and translational research · 2022Article
- Review
- Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HTBritish journal of pharmacology · 2017Article
- Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats.American journal of translational research · 2016Article
- Effect of methysergide on pudendal inhibition of micturition reflex in cats.Experimental neurology · 2013Article
- Effect of mirabegron, a novel β3-adrenoceptor agonist, on bladder function during storage phase in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Pathophysiology of overactive bladder.International urogynecology journal · 2012Review
- The 5-HT(7) receptor in learning and memory.Hippocampus · 2012Review
- Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives.Molecular neurobiology · 2011Review
- Role of 5-HT1A receptors in control of lower urinary tract function in anesthetized rats.American journal of physiology. Renal physiology · 2010Article
- The 5-HT7 receptor and disorders of the nervous system: an overview.Psychopharmacology · 2009Review
- 5-hydroxytryptamine induced relaxation in the pig urinary bladder neck.British journal of pharmacology · 2009Article
- Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.British journal of pharmacology · 2008Article
- The role of central 5-hydroxytryptamine (5-HT, serotonin) receptors in the control of micturition.British journal of pharmacology · 2006Review
- Integrative control of the lower urinary tract: preclinical perspective.British journal of pharmacology · 2006Review
- Central 5-HT7 receptors are critical for reflex activation of cardiac vagal drive in anaesthetized rats.The Journal of physiology · 2005Article
- Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats.British journal of pharmacology · 2003Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) The effects of the selective 5-HT7 receptor antagonists SB-269970 (3-300 microg kg-1; n=5-6) and SB-656104 (30 microg kg-1; n=5) administered centrally (i.c.v.) were investigated on the 'micturition reflex' in the urethane anaesthetized female rat. (2) In cystometric recordings, SB-269970 caused significant increases in volume of 58+/-15 and 138+/-33% and pressure of 140+/-46 and 149+/-60% thresholds at 10 and 30 microg kg-1. These changes were associated with significant decreases in distension-induced bladder contraction of 62+/-14 and 60+/-11%, respectively. However, there was no change in residual volume. At the higher doses, SB-269970 blocked the micturition reflex. SB-656104 had similar effects to SB-269970 but in addition significantly increased the residual volume. (3) SB-269970 (10 microg kg-1; n=5) given i.v. had no effect on the micturition reflex. (4) SB-269970 (30 microg kg-1; n=4) given intrathecally (i.t.) had no effect on micturition reflex, although the selective 5-HT1A receptor antagonist WAY-100635 given i.t. after SB-269970 caused a significant increase in the volume threshold. (5) Using an isovolumetric method in which urethral changes were measured, SB-269970 (30 microg kg-1; n=4; i.c.v.) failed to have any effect on these urethral-evoked changes although they significantly reduced the amplitude of the bladder contraction. (6) These data demonstrate that 5-HT7 receptors located supraspinally in the rat are involved in the control of micturition.
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