ArticleBritish journal of cancer2003
Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Worse breast cancer prognosis of BRCA1/BRCA2 mutation carriers: what's the evidence? A systematic review with meta-analysis.PloS one · 2015Pooled it
- Sexually dimorphic computational histopathological signatures prognostic of overall survival in high-grade gliomas via deep learning.Science advances · 2024Article
- The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer.Pathology international · 2024Article
- Review
- Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches.Cancers · 2020Review
- Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels.The American journal of pathology · 2017Article
- Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer.Oncotarget · 2015Article
- Vascular remodeling in cancer.Oncogene · 2014Review
- Vascular hyperpermeability, angiogenesis, and stroma generation.Cold Spring Harbor perspectives in medicine · 2012Review
- In pursuit of new anti-angiogenic therapies for cancer treatment.Frontiers in bioscience (Landmark edition) · 2011Review
- Identification of the first case of germline duplication of BRCA1 exon 13 in an Italian family.Familial cancer · 2010Article
- Heterogeneity of the tumor vasculature.Seminars in thrombosis and hemostasis · 2010Review
- Crosstalk between the DNA damage response, histone modifications and neovascularisation.The international journal of biochemistry & cell biology · 2010Review
- Triple-negative breast cancer.Breast cancer research : BCR · 2010Review
- BRCA1 and BRCA2: chemosensitivity, treatment outcomes and prognosis.Familial cancer · 2006Review
- Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?Breast cancer research : BCR · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glomeruloid microvascular proliferation (GMP) in breast cancer independently adversely affected survival (relative risk 1.9, 95% CI: 1.2-3.0), particularly among women who received adjuvant chemotherapy (10-year survival 27 vs 69%, P=0.0003), and was significantly associated with p53 overexpression and BRCA1 germline mutations. The presence of GMP may influence treatment decisions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.