ArticleClinical and diagnostic laboratory immunology2003
Periodontitis is associated with a low concentration of vitamin C in plasma.
Article in Clinical and diagnostic laboratory immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2024Pooled it
- Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance.Molecules (Basel, Switzerland) · 2018Pooled it
- Effect of Nutritional Antioxidants on Periodontal Disease and Periodontal Therapy.Dentistry journal · 2025Review
- Evaluation of Serum Vitamin D and C Concentrations in Cats With Gingivostomatitis.Veterinary medicine and science · 2025Article
- Review
- Optimization of Functional Toothpaste Formulation Containing Nano-Hydroxyapatite and Birch Extract for Daily Oral Care.Materials (Basel, Switzerland) · 2023Article
- Relationship between Vitamin D Deficiency and Periodontitis in Korean Adults Aged ≥60 Years: Analysis of Data from the Korea National Health and Nutrition Examination Survey (2013-2014).International journal of environmental research and public health · 2021Article
- The Association between Nutritional Alterations and Oral Lesions in a Pediatric Population: An Epidemiological Study.BioMed research international · 2021Article
- Oxidative Stress in the Local and Systemic Events of Apical Periodontitis.Frontiers in physiology · 2017Review
- The association of dietary vitamin C intake with periodontitis among Korean adults: Results from KNHANES Ⅳ.PloS one · 2017Article
- Chronic Periodontitis in Type 2 Diabetes Mellitus: Oxidative Stress as a Common Factor in Periodontal Tissue Injury.Journal of clinical and diagnostic research : JCDR · 2016Article
- Vegetable and fruit consumption, education and plasma vitamin C concentration in Russian and Finnish Karelia, 1992-2002.Public health nutrition · 2014Article
- Seasonal variation in plasma vitamin C concentration in Pitkäranta, Northwestern Russia.European journal of clinical nutrition · 2013Article
- Antioxidant profile of whole saliva after scaling and root planing in periodontal disease.Journal of periodontal & implant science · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to clarify how concentrations of vitamin C in plasma relate to the serology of periodontitis. The random sample used comprised 431 men, 194 from Finland and 237 from Russia. The plasma vitamin C concentration was determined by o-phtaldialdehyde-fluorometry, and serum immunoglobulin G antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were determined by a multiserotype enzyme-linked immunosorbent assay (ELISA). The mean plasma vitamin C concentration was higher (P < 0.001) in Finnish subjects (mean +/- standard deviation, 4.5 +/- 2.8 mg/liter) than in Russian subjects (1.4 +/- 1.8 mg/liter). Mean antibody levels to both A. actinomycetemcomitans (4.7 +/- 3.6 versus 5.2 +/- 3.1 ELISA units [P = 0.05]) and P. gingivalis (5.7 +/- 2.5 versus 7.6 +/- 2.9 ELISA units [P < 0.001]) were lower in Finnish men than in Russian men. In the combined Finnish and Russian population, the antibody levels to P. gingivalis were negatively correlated with vitamin C concentrations (r = -0.22; P < 0.001); this association remained statistically significant (P = 0.010) in a linear regression model after adjustment for confounding factors. The proportion of P. gingivalis-seropositive subjects decreased with increasing vitamin C concentrations (P for trend, <0.01), but no trend was seen among A. actinomycetemcomitans-seropositive subjects. In conclusion, P. gingivalis infection is associated with low concentrations of vitamin C in plasma, which may increase colonization of P. gingivalis or disturb the healing of the infected periodontium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.