ArticleClinical and diagnostic laboratory immunology2003
Clinical manifestations, epidemiology, and laboratory diagnosis of human monocytotropic ehrlichiosis in a commercial laboratory setting.
Article in Clinical and diagnostic laboratory immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 55 citations in OpenAlex.
- Neurological manifestations of ehrlichiosis among a cohort of patients: prevalence and clinical symptoms.BMC infectious diseases · 2024Article
- Epidemiology of canine ehrlichiosis and molecular characterization of Erhlichia canis in Bangladeshi pet dogs.PloS one · 2024Article
- Microbes and Mental Illness: Past, Present, and Future.Healthcare (Basel, Switzerland) · 2023Review
- Canine and Feline Parasitology: Analogies, Differences, and Relevance for Human Health.Clinical microbiology reviews · 2021Review
- Ehrlichia chaffeensis Outer Membrane Protein 1-Specific Human Antibody-Mediated Immunity Is Defined by Intracellular TRIM21-Dependent Innate Immune Activation and Extracellular Neutralization.Infection and immunity · 2019Article
- Severe human monocytic ehrlichiosis presenting with altered mental status and seizures.BMJ case reports · 2016Article
- An animal model of a newly emerging human ehrlichiosis.The Journal of infectious diseases · 2015Article
- Case report: Molecular evidence of Anaplasma platys infection in two women from Venezuela.The American journal of tropical medicine and hygiene · 2014Article
- Non-lyme tick-borne diseases: a neurological perspective.Current neurology and neuroscience reports · 2013Review
- Emergence of a new pathogenic Ehrlichia species, Wisconsin and Minnesota, 2009.The New England journal of medicine · 2011Article
- Human ehrlichiosis and anaplasmosis.Clinics in laboratory medicine · 2010Review
- Detection and identification of Ehrlichia species in blood by use of PCR and electrospray ionization mass spectrometry.Journal of clinical microbiology · 2010Article
- Predominance of Ehrlichia chaffeensis in Rhipicephalus sanguineus ticks from kennel-confined dogs in Limbe, Cameroon.Experimental & applied acarology · 2010Article
- Pathologic evidence of ehrlichiosis in calves inoculated with Ehrlichia chaffeensis.Annals of the New York Academy of Sciences · 2008Article
- Experimental infection of dairy calves with Ehrlichia chaffeensis.Journal of medical microbiology · 2007Article
- Ehrlichia chaffeensis: a prevalent, life-threatening, emerging pathogen.Transactions of the American Clinical and Climatological Association · 2004Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Clinical, epidemiological, and laboratory diagnostic issues of human monocytotropic ehrlichiosis (HME) were investigated in a retrospective case study conducted at a national reference laboratory (Focus Technologies, formerly MRL Reference Laboratory), and at the University of Texas Medical Branch at Galveston, Texas, during 1997 and 1998. Standard questionnaires were sent to physicians for each laboratory-diagnosed patient 2 days to 2 weeks after immunofluorescent antibody assay results were available. Among the 41 cases for which data were obtained, 32 (78%) were definite cases of HME, and 9 (22%) were probable cases of HME. Tick bite or exposure to ticks was recorded in more than 97% of cases. The most prominent clinical findings were fever, abdominal tenderness, and regional lymphadenopathy. There was an association between age and severity of illness. The main laboratory findings included leukopenia, thrombocytopenia, and elevated aspartate aminotransferase and alanine aminotransferase. Clinical and laboratory findings were nonspecific and were not good predictors of the severity of illness. The 90% of patients who received doxycycline treatment underwent rapid clinical improvement with a favorable outcome. The usual duration of effective treatment with doxycycline was 7 to 10 days. This retrospective study is unique because it was based in a commercial reference laboratory setting that receives specimens from different geographic locations. The clinical and laboratory information from 41 patients provides insight into the epidemiological, clinical, and laboratory characteristics of HME.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.