Evidence map›Paper›PMID 12965897›Full record

ArticleClinical and diagnostic laboratory immunology2003

High levels of interleukin-1 in patients with endemic pemphigus foliaceus.

Denise Bertulucci Rocha-Rodrigues, Giovana Paschoini, Sanivia Aparecida Lima Pereira, Marlene Antonia dos Reis, Vicente de Paula Antunes Teixeira, Virmondes Rodrigues Júnior

Open access · diamondAbstract read
In one paragraph

Article in Clinical and diagnostic laboratory immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. CD4Current molecular medicine · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Endemic pemphigus over a century: Part II.North American journal of medical sciences · 2010
    Article
  10. Fogo selvagem: endemic pemphigus foliaceus.Anais brasileiros de dermatologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Denise Bertulucci Rocha-RodriguesFaculdade de Medicina do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
Giovana Paschoini
Sanivia Aparecida Lima Pereira
Marlene Antonia dos Reis
Vicente de Paula Antunes Teixeira
Virmondes Rodrigues Júnior
Universidade Federal do Triângulo Mineiro · BRUniversidade de Uberaba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response.

Indexed as

Autoimmune DiseasesCytokinesHumansInterferon-gammaInterleukin-1Interleukin-5Leukocytes, MononuclearPemphigusTh2 CellsTumor Necrosis Factor-alphaCytokinesInterferon-gammaInterleukin-1Interleukin-5Tumor Necrosis Factor-alpha

Identifiers

PMID12965897
PMCPMC193914
OpenAlexW2155867637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.