ArticleProceedings. Biological sciences2003
Towards the delineation of the ancestral eutherian genome organization: comparative genome maps of human and the African elephant (Loxodonta africana) generated by chromosome painting.
Article in Proceedings. Biological sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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35 citing papers in PubMed.
- Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample.Cell · 2024Article
- Establishment of Primary Adult Skin Fibroblast Cell Lines from African Savanna Elephants (Animals : an open access journal from MDPI · 2023Article
- Supernumerary Marker Chromosome Identified in Asian Elephant (Animals : an open access journal from MDPI · 2023Article
- Article
- Convergent evolution of a genomic rearrangement may explain cancer resistance in hystrico- and sciuromorpha rodents.NPJ aging and mechanisms of disease · 2021Article
- Reconstruction and evolutionary history of eutherian chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A First Generation Comparative Chromosome Map between Guinea Pig (Cavia porcellus) and Humans.PloS one · 2015Article
- Praomys tullbergi (Muridae, Rodentia) genome architecture decoded by comparative chromosome painting with Mus and Rattus.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Chromosome painting in three-toed sloths: a cytogenetic signature and ancestral karyotype for Xenarthra.BMC evolutionary biology · 2012Article
- Review
- The genome diversity and karyotype evolution of mammals.Molecular cytogenetics · 2011Article
- High-resolution chromosome painting reveals the first genetic signature for the chiropteran suborder Pteropodiformes (Mammalia: Chiroptera).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Reconstruction of karyotype evolution in core Glires. I. The genome homology revealed by comparative chromosome painting.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- A second generation genetic map of the bumblebee Bombus terrestris (Linnaeus, 1758) reveals slow genome and chromosome evolution in the Apidae.BMC genomics · 2011Article
- Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species.Immunogenetics · 2010Review
- Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution.PLoS genetics · 2009Article
- Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution.BMC evolutionary biology · 2009Article
- A methodological framework for the reconstruction of contiguous regions of ancestral genomes and its application to mammalian genomes.PLoS computational biology · 2008Article
- Hemiplasy and homoplasy in the karyotypic phylogenies of mammals.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Flying lemurs--the 'flying tree shrews'? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade.BMC biology · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
This study presents a whole-genome comparison of human and a representative of the Afrotherian clade, the African elephant, generated by reciprocal Zoo-FISH. An analysis of Afrotheria genomes is of special interest, because recent DNA sequence comparisons identify them as the oldest placental mammalian clade. Complete sets of whole-chromosome specific painting probes for the African elephant and human were constructed by degenerate oligonucleotide-primed PCR amplification of flow-sorted chromosomes. Comparative genome maps are presented based on their hybridization patterns. These maps show that the elephant has a moderately rearranged chromosome complement when compared to humans. The human paint probes identified 53 evolutionary conserved segments on the 27 autosomal elephant chromosomes and the X chromosome. Reciprocal experiments with elephant probes delineated 68 conserved segments in the human genome. The comparison with a recent aardvark and elephant Zoo-FISH study delineates new chromosomal traits which link the two Afrotherian species phylogenetically. In the absence of any morphological evidence the chromosome painting data offer the first non-DNA sequence support for an Afrotherian clade. The comparative human and elephant genome maps provide new insights into the karyotype organization of the proto-afrotherian, the ancestor of extant placental mammals, which most probably consisted of 2n=46 chromosomes.
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