ArticleProceedings. Biological sciences2003
Dynamics of individual sarcomeres during and after stretch in activated single myofibrils.
Article in Proceedings. Biological sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- The Contraction Modalities in a Stretch-Shortening Cycle in Animals and Single Joint Movements in Humans: A Systematic Review.Journal of sports science & medicine · 2019Pooled it
- Mechanisms Influencing Maximum Joint Range of Motion and Stiffness: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2026Review
- Neuromechanical basis of region-specific differences and their implications for sport performance and injury prevention: a narrative review.European journal of applied physiology · 2025Review
- Biomechanical evaluation of flash-frozen and cryo-sectioned papillary muscle samples by using sinusoidal analysis: cross-bridge kinetics and the effect of partial CaJournal of muscle research and cell motility · 2024Article
- Oscillatory work and the step that generates force in single myofibrils from rabbit psoas.Pflugers Archiv : European journal of physiology · 2024Article
- Re‑examining the mechanism of eccentric exercise‑induced skeletal muscle damage from the role of the third filament, titin (Review).Biomedical reports · 2024Review
- Characterizing residual and passive force enhancements in cardiac myofibrils.Biophysical journal · 2023Article
- Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics.Pflugers Archiv : European journal of physiology · 2023Review
- Gaining new understanding of sarcomere length non-uniformities in skeletal muscles.Frontiers in physiology · 2023Article
- Phosphate has dual roles in cross-bridge kinetics in rabbit psoas single myofibrils.The Journal of general physiology · 2021Article
- Sarcomere length non-uniformities dictate force production along the descending limb of the force-length relation.Proceedings. Biological sciences · 2020Article
- Contribution of Stretch-Induced Force Enhancement to Increased Performance in Maximal Voluntary and Submaximal Artificially Activated Stretch-Shortening Muscle Action.Frontiers in physiology · 2020Article
- Mechano-Electric Coupling and Arrhythmogenic Current Generation in a Computational Model of Coupled Myocytes.Frontiers in physiology · 2020Article
- Arrhythmogenic Current Generation by Myofilament-Triggered CaBiophysical journal · 2019Article
- Does partial titin degradation affect sarcomere length nonuniformities and force in active and passive myofibrils?American journal of physiology. Cell physiology · 2018Article
- Different Segments within Vertebrate Muscles Can Operate on Different Regions of Their Force-Length Relationships.Integrative and comparative biology · 2018Article
- The multiple roles of titin in muscle contraction and force production.Biophysical reviews · 2018Review
- Titin-mediated thick filament activation stabilizes myofibrils on the descending limb of their force-length relationship.Journal of sport and health science · 2018Article
- Why are muscles strong, and why do they require little energy in eccentric action?Journal of sport and health science · 2018Article
- Sarcomere Stiffness during Stretching and Shortening of Rigor Skeletal Myofibrils.Biophysical journal · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is generally assumed that sarcomere lengths (SLs) change in isometric fibres following activation and following stretch on the descending limb of the force-length relationship, because of an inherent instability. Although this assumption has never been tested directly, instability and SL non-uniformity have been associated with several mechanical properties, such as 'creep' and force enhancement. The aim of this study was to test directly the hypothesis that sarcomeres are unstable on the descending limb of the force-length relationship. We used single myofibrils, isolated from rabbit psoas, that were attached to glass needles that allowed for controlled stretching of myofibrils. Images of the sarcomere striation pattern were projected onto a linear photodiode array, which was scanned at 20 Hz to produce dark-light patterns corresponding to the A- and I-bands, respectively. Starting from a mean SL of 2.55 +/- 0.07 microm, stretches of 11.2 +/- 1.6% of SL at a speed of 118.9 +/- 5.9 nm s(-1) were applied to the activated myofibrils (pCa(2+) = 4.75). SLs along the myofibril were non-uniform before, during and after the stretch, but with few exceptions, they remained constant during the isometric period before stretch, and during the extended isometric period after stretch. Sarcomeres never lengthened to a point beyond thick and thin filament overlap. We conclude that sarcomeres are non-uniform but generally stable on the descending limb of the force-length relationship.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.