ArticleThe Journal of physiology2003
Voltage-gated Na+ channel activation induces both action potentials in utricular hair cells and brain-derived neurotrophic factor release in the rat utricle during a restricted period of development.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Multi-omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells.Experimental physiology · 2026Article
- Quantifying calretinin-labeled afferent terminals in vestibular sensory epithelia of young and older gerbils.Neurobiology of aging · 2026Article
- Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley.Trends in cell biology · 2025Review
- Pimozide Inhibits Type II but Not Type I Hair Cells in Chicken Embryo and Adult Mouse Vestibular Organs.Biomedicines · 2024Article
- The Differentiation Status of Hair Cells That Regenerate Naturally in the Vestibular Inner Ear of the Adult Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Expression and Physiology of Voltage-Gated Sodium Channels in Developing Human Inner Ear.Frontiers in neuroscience · 2021Article
- Peripheral vestibular plasticity vs central compensation: evidence and questions.Journal of neurology · 2019Review
- Regional and Developmental Differences in NaFrontiers in cellular neuroscience · 2018Article
- Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs.Development (Cambridge, England) · 2016Article
- Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.Nature communications · 2016Article
- Preliminary characterization of voltage-activated whole-cell currents in developing human vestibular hair cells and calyx afferent terminals.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Functional features of trans-differentiated hair cells mediated by Atoh1 reveals a primordial mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings.PloS one · 2012Article
- Development and function of the voltage-gated sodium current in immature mammalian cochlear inner hair cells.PloS one · 2012Article
- Plasticity of Scarpa's Ganglion Neurons as a Possible Basis for Functional Restoration within Vestibular Endorgans.Frontiers in neurology · 2012Article
- Molecular microdomains in a sensory terminal, the vestibular calyx ending.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Regulation of Kv channel expression and neuronal excitability in rat medial nucleus of the trapezoid body maintained in organotypic culture.The Journal of physiology · 2010Article
- Perisomatic voltage-gated sodium channels actively maintain linear synaptic integration in principal neurons of the medial superior olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Development of K(+) and Na(+) conductances in rodent postnatal semicircular canal type I hair cells.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Ion channel gene expression in the inner ear.Journal of the Association for Research in Otolaryngology : JARO · 2007Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian utricular sensory receptors are commonly believed to be non-spiking cells with electrical activity limited to graded membrane potential changes. Here we provide evidence that during the first post-natal week, the sensory hair cells of the rat utricle express a tetrodotoxin (TTX)-sensitive voltage-gated Na+ current that displays most of the biophysical and pharmacological characteristics of neuronal Na+ current. Single-cell RT-PCR reveals that several alpha-subunit isoforms of the Na+ channels are co-expressed within a single hair cell, with a major expression of Nav1.2 and Nav1.6 subunits. In neonatal hair cells, 30 % of the Na+ channels are available for activation at the resting potential. Depolarizing current injections in the range of the transduction currents are able to trigger TTX-sensitive action potentials. We also provide evidence of a TTX-sensitive activity-dependent brain-derived neurotrophic factor (BDNF) release by early post-natal utricle explants. Developmental analysis shows that Na+ currents decrease dramatically from post-natal day 0 (P0) to P8 and become almost undetectable at P21. Concomitantly, depolarizing stimuli fail to induce both action potential and BDNF release at P20. The present findings reveal that vestibular hair cells express neuronal-like TTX-sensitive Na+ channels able to generate Na+-driven action potentials only during the early post-natal period of development. During the same period an activity-dependent BDNF secretion by utricular explants has been demonstrated. This could be an important mechanism involved in vestibular sensory system differentiation and synaptogenesis.
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