ArticleThe Journal of physiology2003
Adenosine A(1) receptor-mediated presynaptic inhibition at the calyx of Held of immature rats.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine.Frontiers in cellular neuroscience · 2025Article
- Purinergic Modulation of Activity in the Developing Auditory Pathway.Neuroscience bulletin · 2020Review
- A Role of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytic Aβ Clearance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Adenosine AAnatomical record (Hoboken, N.J. : 2007) · 2018Article
- NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups.Open biology · 2017Article
- Glycolysis selectively shapes the presynaptic action potential waveform.Journal of neurophysiology · 2016Article
- Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.Journal of neurophysiology · 2015Article
- Modulation of synaptic depression of the calyx of Held synapse by GABA(B) receptors and spontaneous activity.The Journal of physiology · 2013Article
- Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus.The Journal of physiology · 2013Article
- Formation and maturation of the calyx of Held.Hearing research · 2011Review
- Thalamocortical dynamics of sleep: roles of purinergic neuromodulation.Seminars in cell & developmental biology · 2011Review
- The dynamics of single spike-evoked adenosine release in the cerebellum.The Journal of physiology · 2011Article
- A1 receptors self-regulate adenosine release in the striatum: evidence of autoreceptor characteristics.Neuroscience · 2010Article
- Developmental shift to a mechanism of synaptic vesicle endocytosis requiring nanodomain Ca2+.Nature neuroscience · 2010Article
- Adenosine signalling at immature parallel fibre-Purkinje cell synapses in rat cerebellum.The Journal of physiology · 2009Article
- The principal neurons of the medial nucleus of the trapezoid body and NG2(+) glial cells receive coordinated excitatory synaptic input.The Journal of general physiology · 2009Article
- Article
- Activity-dependent release of adenosine: a critical re-evaluation of mechanism.Current neuropharmacology · 2008Article
- Involvement of AMPA receptor desensitization in short-term synaptic depression at the calyx of Held in developing rats.The Journal of physiology · 2008Article
- Developmental changes in calcium/calmodulin-dependent inactivation of calcium currents at the rat calyx of Held.The Journal of physiology · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At the calyx of Held synapse in brainstem slices of 5- to 7-day-old (P5-7) rats, adenosine, or the type 1 adenosine (A1) receptor agonist N6-cyclopentyladenosine (CPA), inhibited excitatory postsynaptic currents (EPSCs) without affecting the amplitude of miniature EPSCs. The A1 receptor antagonist 8-cyclopentyltheophylline (CPT) had no effect on the amplitude of EPSCs evoked at a low frequency, but significantly reduced the magnitude of synaptic depression caused by repetitive stimulation at 10 Hz, suggesting that endogenous adenosine is involved in the regulation of transmitter release. Adenosine inhibited presynaptic Ca(2+) currents (IpCa) recorded directly from calyceal terminals, but had no effect on presynaptic K+ currents. When EPSCs were evoked by IpCa during simultaneous pre- and postsynaptic recordings, the magnitude of the adenosine-induced inhibition of IpCa fully explained that of EPSCs, suggesting that the presynaptic Ca(2+) channel is the main target of A1 receptors. Whereas the N-type Ca(2+) channel blocker omega-conotoxin attenuated EPSCs, it had no effect on the magnitude of adenosine-induced inhibition of EPSCs. During postnatal development, in parallel with a decrease in the A1 receptor immunoreactivity at the calyceal terminal, the inhibitory effect of adenosine became weaker. We conclude that presynaptic A1 receptors at the immature calyx of Held synapse play a regulatory role in transmitter release during high frequency transmission, by inhibiting multiple types of presynaptic Ca(2+) channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.