ArticleJournal of molecular evolution2003
Evolution of TRG clusters in cattle and sheep genomes as drawn from the structural analysis of the ovine TRG2@ locus.
Article in Journal of molecular evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 40 citations in OpenAlex.
- IMGTAntibodies (Basel, Switzerland) · 2026Review
- From benchmarking alignment of genome assemblies to IMGT annotation: the paradigm of the bovine Bos taurus T cell receptor (TRG) locus.BMC genomics · 2025Article
- The T Cell Receptor (TRB) Locus inGenes · 2021Article
- Characterization of the domestic goat γδ T cell receptor gene loci and gene usage.Immunogenetics · 2021Article
- TR Locus Annotation and Characteristics ofFrontiers in immunology · 2021Article
- The expansion of the TRB and TRG genes in domestic goats (Capra hircus) is characteristic of the ruminant species.BMC genomics · 2020Article
- Review
- The Camel Adaptive Immune Receptors Repertoire as a Singular Example of Structural and Functional Genomics.Frontiers in genetics · 2019Review
- Identification and characterization of TCRγ and TCRδ chains in channel catfish, Ictalurus punctatus.Immunogenetics · 2014Article
- Structural and comparative analysis of the T cell receptor gamma (TRG) locus in Oryctolagus cuniculus.Immunogenetics · 2012Article
- Extensive analysis of D-J-C arrangements allows the identification of different mechanisms enhancing the diversity in sheep T cell receptor beta-chain repertoire.BMC genomics · 2010Article
- Article
- Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domestica.BMC genomics · 2008Article
- Genomic organization and recombinational unit duplication-driven evolution of ovine and bovine T cell receptor gamma loci.BMC genomics · 2008Article
- Molecular in situ hybridization analysis of sheep and goat BAC clones identifies the transcriptional orientation of T cell receptor gamma genes on chromosome 4 in bovids.Veterinary research communications · 2007Article
- Identification of three new bovine T-cell receptor delta variable gene subgroups expressed by peripheral blood T cells.Immunogenetics · 2006Article
- Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells.Immunogenetics · 2006Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The availability of genomic clones representative of the T-cell receptor constant gamma (TRGC) ovine genes enabled us to demonstrate, by fluorescent in situ hybridization (FISH) on cattle and sheep metaphases, the presence of two T-cell receptor gamma (TRG1@ and TRG2@) paralogous loci separated by at least five chromosomal bands on chromosome 4. Only TRG1@ is included within a region of homology with human TRG locus on chromosome 7, thus TRG2@ locus appears to be peculiar to ruminants. The structure of the entire TRG2@ locus, the first complete physical map of any ruminant animal TCR gamma locus, is reported here. The TRG2@ spans about 90 kb and consists of three clusters that we named TRG6, TRG2, and TRG4, according to the constant genes name. Phylogenetic analysis has highlighted the correlation between the grouping pattern of cattle and sheep variable gamma (TRGV) genes and the relevant TRGC; variable (V), joining (J), and constant (C) rearrange to be found together in mature transcripts. The simultaneous results on the TRG2@ locus molecular organization in sheep and on the phylogenetic analysis of cattle and sheep V expressed sequences indicate that at least six TRG clusters distributed in the two loci are present in these ruminant animals. The inferred evolution of TRG clusters in cattle and sheep genomes is consistent with a scenario where a minimal ancient cluster, containing the basic structural scheme of one V, one J, and one C gene, has undergone a process of duplication and intrachromosomal transposition.
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