ArticleMolecular and cellular biochemistry2003
Mechanism of glycogen supercompensation in rat skeletal muscle cultures.
Article in Molecular and cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Differential expression of HIF-1α and its hypoxia-related inducers in the spleens of plateau yaks and plain yellow cattle.Histology and histopathology · 2025Article
- Hypoxia-Induced Differences in the Expression of Pyruvate Dehydrogenase Kinase 1-Related Factors in the Renal Tissues and Renal Interstitial Fibroblast-like Cells of Yak (Bos Grunniens).Animals : an open access journal from MDPI · 2024Article
- The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise.Sports medicine and health science · 2023Review
- A century of exercise physiology: key concepts in regulation of glycogen metabolism in skeletal muscle.European journal of applied physiology · 2022Review
- Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma.Signal transduction and targeted therapy · 2020Article
- Gintonin, a Ginseng-Derived Exogenous Lysophosphatidic Acid Receptor Ligand, Protects Astrocytes from Hypoxic and Re-oxygenation Stresses Through Stimulation of Astrocytic Glycogenolysis.Molecular neurobiology · 2019Article
- Leucine-Enriched Essential Amino Acids Augment Muscle Glycogen Content in Rats Seven Days after Eccentric Contraction.Nutrients · 2017Article
- Weak electromagnetic fields alter Ca(2+) handling and protect against hypoxia-mediated damage in primary newborn rat myotube cultures.Pflugers Archiv : European journal of physiology · 2016Article
- Article
- Hexokinase 2, glycogen synthase and phosphorylase play a key role in muscle glycogen supercompensation.PloS one · 2012Article
- Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1.PloS one · 2010Article
- A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.Genes & development · 2007Article
- Insulin-independent glycogen supercompensation in isolated mouse skeletal muscle: role of phosphorylase inactivation.Pflugers Archiv : European journal of physiology · 2004Article
- Glycogen metabolism in rat heart muscle cultures after hypoxia.Molecular and cellular biochemistry · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A model to study glycogen supercompensation (the significant increase in glycogen content above basal level) in primary rat skeletal muscle culture was established. Glycogen was completely depleted in differentiated myotubes by 2 h of electrical stimulation or exposure to hypoxia during incubation in medium devoid of glucose. Thereafter, cells were incubated in medium containing glucose, and glycogen supercompensation was clearly observed in treated myotubes after 72 h. Peak glycogen levels were obtained after 120 h, averaging 2.5 and 4 fold above control values in the stimulated- and hypoxia-treated cells, respectively. Glycogen synthase activity increased and phosphorylase activity decreased continuously during 120 h of recovery in the treated cells. Rates of 2-deoxyglucose uptake were significantly elevated in the treated cells at 96 and 120 h, averaging 1.4-2 fold above control values. Glycogenin content increased slightly in the treated cells after 48 h (1.2 fold vs. control) and then increased considerably, achieving peak values after 120 h (2 fold vs. control). The results demonstrate two phases of glycogen supercompensation: the first phase depends primarily on activation of glycogen synthase and inactivation of phosphorylase; the second phase includes increases in glucose uptake and glycogenin level.
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