ArticleMolecular biology of the cell2003
Rapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and Cbl.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Microtubule stability modulates Schlemm's canal cell mechanobiology and outflow facility in glaucoma.bioRxiv : the preprint server for biology · 2026Article
- ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium.Theranostics · 2024Article
- Emerging evidence on Monkeypox: resurgence, global burden, molecular insights, genomics and possible management.Frontiers in cellular and infection microbiology · 2023Review
- Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression.PloS one · 2015Article
- Article
- SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function.PLoS genetics · 2012Article
- Gene expression profiling of monkeypox virus-infected cells reveals novel interfaces for host-virus interactions.Virology journal · 2010Article
- Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.Cell cycle (Georgetown, Tex.) · 2010Review
- Neuronal differentiation by analogs of staurosporine.Neurochemistry international · 2010Article
- The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.Molecular biology of the cell · 2007Article
- c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl.Oncogene · 2007Article
- The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.Molecular biology of the cell · 2007Article
- Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.Molecular biology of the cell · 2005Article
- Clues to CD2-associated protein involvement in cytokinesis.Molecular biology of the cell · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of key cellular functions, such as morphological differentiation and cell motility, are closely associated with changes in cytoskeletal dynamics. Many of the principal signaling components involved in actin cytoskeletal dynamics have been identified, and these have been shown to be critically involved in cell motility. In contrast, signaling to microtubules remains relatively uncharacterized, and the importance of signaling pathways in modulation of microtubule dynamics has so far not been established clearly. We report here that the Rho-effector ROCK and the multiadaptor proto-oncoprotein Cbl can profoundly affect the microtubule cytoskeleton. Simultaneous inhibition of these two signaling molecules induces a dramatic rearrangement of the microtubule cytoskeleton into microtubule bundles. The formation of these microtubule bundles, which does not involve signaling by Rac, Cdc42, Crk, phosphatidylinositol 3-kinase, and Abl, is sufficient to induce distinct neurite-like extensions in NIH 3T3 fibroblasts, even in the absence of microfilaments. This novel microtubule-dependent function that promotes neurite-like extensions is not dependent on net changes in microtubule polymerization or stabilization, but rather involves selective elongation and reorganization of microtubules into long bundles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.