ArticleMolecular biology of the cell2003
Sec3p is needed for the spatial regulation of secretion and for the inheritance of the cortical endoplasmic reticulum.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 113 citations in OpenAlex.
- Viral vaccines promote endoplasmic reticulum stress-induced unfolding protein response in teleost erythrocytes.European journal of cell biology · 2025Article
- SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023Article
- High-resolution secretory timeline from vesicle formation at the Golgi to fusion at the plasma membrane ineLife · 2022Article
- The Exocyst Regulates Hydrolytic Enzyme Secretion at Hyphal Tips and Septa in the Banana Fusarium Wilt Fungus Fusarium odoratissimum.Applied and environmental microbiology · 2021Article
- Regulation of the early stages of endoplasmic reticulum inheritance during ER stress.Molecular biology of the cell · 2021Article
- Cdc42 GTPase regulates ESCRTs in nuclear envelope sealing and ER remodeling.The Journal of cell biology · 2020Article
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- Cyclin-dependent kinase-mediated phosphorylation of the exocyst subunit Exo84 in late GThe Journal of biological chemistry · 2019Article
- Exocyst dynamics during vesicle tethering and fusion.Nature communications · 2018Article
- Exposing the Elusive Exocyst Structure.Trends in biochemical sciences · 2018Review
- Disruption of OsSEC3A increases the content of salicylic acid and induces plant defense responses in rice.Journal of experimental botany · 2018Article
- Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion.Nature communications · 2017Article
- Cell cycle-dependent phosphorylation of Sec4p controls membrane deposition during cytokinesis.The Journal of cell biology · 2016Article
- The Exocyst Complex in Health and Disease.Frontiers in cell and developmental biology · 2016Review
- Septin-Dependent Assembly of the Exocyst Is Essential for Plant Infection by Magnaporthe oryzae.The Plant cell · 2015Article
- Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics.Scientific reports · 2015Article
- A protein complex containing Epo1p anchors the cortical endoplasmic reticulum to the yeast bud tip.The Journal of cell biology · 2015Article
- The role of Sec3p in secretory vesicle targeting and exocyst complex assembly.Molecular biology of the cell · 2014Article
- Plant cell shape: modulators and measurements.Frontiers in plant science · 2013Review
- Different polarisome components play distinct roles in Slt2p-regulated cortical ER inheritance in Saccharomyces cerevisiae.Molecular biology of the cell · 2013Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sec3p is a component of the exocyst complex that tethers secretory vesicles to the plasma membrane at exocytic sites in preparation for fusion. Unlike all other exocyst structural genes, SEC3 is not essential for growth. Cells lacking Sec3p grow and secrete surprisingly well at 25 degrees C; however, late markers of secretion, such as the vesicle marker Sec4p and the exocyst subunit Sec8p, localize more diffusely within the bud. Furthermore, sec3Delta cells are strikingly round relative to wild-type cells and are unable to form pointed mating projections in response to alpha factor. These phenotypes support the proposed role of Sec3p as a spatial landmark for secretion. We also find that cells lacking Sec3p exhibit a dramatic defect in the inheritance of cortical ER into the bud, whereas the inheritance of mitochondria and Golgi is unaffected. Overexpression of Sec3p results in a prominent patch of the endoplasmic reticulum (ER) marker Sec61p-GFP at the bud tip. Cortical ER inheritance in yeast has been suggested to involve the capture of ER tubules at the bud tip. Sec3p may act in this process as a spatial landmark for cortical ER inheritance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.