ArticleMolecular biology of the cell2003
Diffusion-based transport of nascent ribosomes in the nucleus.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 81 citations in OpenAlex.
- Translation landscape of stress granules.Science advances · 2025Article
- Pre-ribosomal particles from nucleoli to cytoplasm.Nucleus (Austin, Tex.) · 2024Review
- An Intermittent Cytochemist.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023Article
- Modelling the effect of ribosome mobility on the rate of protein synthesis.The European physical journal. E, Soft matter · 2021Article
- Crowd Control: Effects of Physical Crowding on Cargo Movement in Healthy and Diseased Neurons.Frontiers in cellular neuroscience · 2019Review
- Protein Neighbors and Proximity Proteomics.Molecular & cellular proteomics : MCP · 2015Review
- Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Subcellular mRNA localisation at a glance.Journal of cell science · 2014Review
- Early endosome motility spatially organizes polysome distribution.The Journal of cell biology · 2014Article
- A mRNA and cognate microRNAs localize in the nucleolus.Nucleus (Austin, Tex.) · 2014Article
- Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- The nucleolus: a raft adrift in the nuclear sea or the keystone in nuclear structure?Biomolecular concepts · 2013Review
- Article
- The nucleolar detention pathway: A cellular strategy for regulating molecular networks.Cell cycle (Georgetown, Tex.) · 2012Article
- Measuring the flow of molecules in cells.Biophysical reviews · 2011Review
- The nucleus introduced.Cold Spring Harbor perspectives in biology · 2011Review
- The nucleolus.Cold Spring Harbor perspectives in biology · 2011Review
- Chromosome dynamics, molecular crowding, and diffusion in the interphase cell nucleus: a Monte Carlo lattice simulation study.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- In vivo pair correlation analysis of EGFP intranuclear diffusion reveals DNA-dependent molecular flow.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although the complex process of ribosome assembly in the nucleolus is beginning to be understood, little is known about how the ribosomal subunits move from the nucleolus to the nuclear membrane for transport to the cytoplasm. We show here that large ribosomal subunits move out from the nucleolus and into the nucleoplasm in all directions, with no evidence of concentrated movement along directed paths. Mobility was slowed compared with that expected in aqueous solution in a manner consistent with anomalous diffusion. Once nucleoplasmic, the subunits moved in the same random manner and also sometimes visited another nucleolus before leaving the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.