ArticleProceedings of the National Academy of Sciences of the United States of America2003
Intra-G1 arrest in response to UV irradiation in fission yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Activation of Gcn2 in response to different stresses.PloS one · 2017Article
- Stress-induced inhibition of translation independently of eIF2α phosphorylation.Journal of cell science · 2015Article
- Article
- Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.BMC genomics · 2012Article
- Induction of a G1-S checkpoint in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Hpz1 modulates the G1-S transition in fission yeast.PloS one · 2012Article
- Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.Nucleic acids research · 2011Article
- UV-B-induced DNA damage mediates expression changes of cell cycle regulatory genes in Arabidopsis root tips.Planta · 2011Article
- Global transcriptional response after exposure of fission yeast cells to ultraviolet light.BMC cell biology · 2009Article
- Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.Molecular and cellular biology · 2009Article
- A novel checkpoint mechanism regulating the G1/S transition.Genes & development · 2007Article
- DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1.EMBO reports · 2006Article
- Germinating fission yeast spores delay in G1 in response to UV irradiation.BMC cell biology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
G1 is a crucial phase of cell growth because the decision to begin another mitotic cycle is made during this period. Occurrence of DNA damage in G1 poses a particular challenge, because replication of damaged DNA can be deleterious and because no sister chromatid is present to provide a template for recombinational repair. We therefore have studied the response of Schizosaccharomyces pombe cells to UV irradiation in early G1 phase. We find that irradiation results in delayed progression through G1, as manifested most critically in the delayed formation of the pre-replication complex. This delay does not have the molecular hallmarks of known checkpoint responses: it is independent of the checkpoint proteins Rad3, Cds1, and Chk1 and does not elicit inhibitory phosphorylation of Cdc2. Irradiated cells eventually progress into S phase and arrest in early S by a rad3- and cds1-dependent mechanism, most likely the intra-S checkpoint. Caffeine alleviates both the intra-G1- and intra-S-phase delays. We suggest that intra-G1 delay may be widely conserved and discuss significance and possible mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.