ArticleProceedings of the National Academy of Sciences of the United States of America2003
Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- Elevation of IL-8 secretion induced by PEDV infection via NF-κB signaling pathway.Frontiers in cellular and infection microbiology · 2024Article
- Treatment with Peanut Sprout Root Extract Alleviates Inflammation in a Lipopolysaccharide-Stimulated Mouse Macrophage Cell Line by Inhibiting the MAPK Signaling Pathway.International journal of molecular sciences · 2019Article
- Single stranded (ss)RNA-mediated antiviral response against infectious laryngotracheitis virus infection.BMC microbiology · 2019Article
- Antiviral response elicited against avian influenza virus infection following activation of toll-like receptor (TLR)7 signaling pathway is attributable to interleukin (IL)-1β production.BMC research notes · 2018Article
- Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein.Journal of virology · 2018Article
- Characterizing the Cellular Immune Response to Parainfluenza Virus 3.The Journal of infectious diseases · 2017Article
- Quantitative Analysis of Cellular Proteome Alterations in CDV-Infected Mink Lung Epithelial Cells.Frontiers in microbiology · 2017Article
- Enhanced growth of influenza A virus by coinfection with human parainfluenza virus type 2.Medical microbiology and immunology · 2016Article
- Regulation of TLR3 Activation by S100A9.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Nedd8 regulates inflammasome-dependent caspase-1 activation.Molecular and cellular biology · 2015Article
- Smac mimetics and innate immune stimuli synergize to promote tumor death.Nature biotechnology · 2014Article
- DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway.PLoS pathogens · 2014Article
- A quantitative infection assay for human type I, II, and III interferon antiviral activities.Virology journal · 2013Article
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- Inhibition of Acute Phase Inflammation by Laminaria japonica through Regulation of iNOS-NF- κ B Pathway.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease.Journal of virology · 2012Article
- Bojesodok-eum, a Herbal Prescription, Ameliorates Acute Inflammation in Association with the Inhibition of NF-κB-Mediated Nitric Oxide and ProInflammatory Cytokine Production.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Mitogen-activated protein kinase-dependent interleukin-1α intracrine signaling is modulated by YopP during Yersinia enterocolitica infection.Infection and immunity · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NF-kappaB is known to exert its antiviral innate immune response via the IFN-beta-induced Janus kinase/signal transducers and activators of transcription pathway. However, our current studies have demonstrated that activated NF-kappaB is capable of directly establishing an antiviral state independent of IFN or secreted soluble factor(s) against two highly pathogenic respiratory RNA viruses. Human parainfluenza virus type 3, a mildly cytopathic virus that induced NF-kappaB very early during infection was converted to a virulent virus after NF-kappaB inhibition. In contrast, a highly cytopathic virus, human respiratory syncytial virus that induced NF-kappaB late during infection, was converted to a mildly cytopathic virus after NF-kappaB induction before virus replication. This interconversion of cytopathic phenotypes of viruses after NF-kappaB modulation was further shown to be independent of IFN and soluble secreted factors(s). Moreover, tumor necrosis factor alpha (TNF-alpha) and IL-1beta elicited an antiviral response, which was NF-kappaB-dependent. Thus, NF-kappaB induction directly confers an essential innate antiviral response against human parainfluenza virus type 3 and respiratory syncytial virus, which is independent of IFN-inducible factor(s).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.