ArticleProceedings of the National Academy of Sciences of the United States of America2003
Resistance of virus to extinction on bottleneck passages: study of a decaying and fluctuating pattern of fitness loss.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 107 citations in OpenAlex.
- Quasispecies productivity.Die Naturwissenschaften · 2024Article
- Standing Genetic Diversity and Transmission Bottleneck Size Drive Adaptation in Bacteriophage Qβ.International journal of molecular sciences · 2022Article
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- Genomic profile of eGFP-expressing canine distemper virus that undergoes serial plaque-to-plaque transfers.Frontiers in cellular and infection microbiology · 2022Article
- The Intrapopulation Genetic Diversity of RNA Virus May Influence the Sensitivity of Chlorine Disinfection.Frontiers in microbiology · 2022Article
- Intra-Population Competition during Adaptation to Increased Temperature in an RNA Bacteriophage.International journal of molecular sciences · 2021Article
- Viability of SARS-CoV-2 in river water and wastewater at different temperatures and solids content.Water research · 2021Article
- Infection Kinetics and Transmissibility of a Reanimated Dengue Virus Serotype 4 Identified Originally in WildFrontiers in microbiology · 2021Article
- SustainedVirus evolution · 2019Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Quasispecies and virus.European biophysics journal : EBJ · 2018Review
- Differences in adaptive dynamics determine the success of virus variants that propagate together.Virus evolution · 2018Article
- Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity.Journal of virology · 2017Article
- Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression.Journal of virology · 2017Article
- Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment.Journal of virology · 2017Article
- Article
- Inevitability of Genetic Parasites.Genome biology and evolution · 2016Article
- Changes in protein domains outside the catalytic site of the bacteriophage Qβ replicase reduce the mutagenic effect of 5-azacytidine.Journal of virology · 2014Article
- Quantitative modeling of virus evolutionary dynamics and adaptation in serial passages using empirically inferred fitness landscapes.Journal of virology · 2014Article
- Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain.Virology journal · 2013Article
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5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA viruses display high mutation rates and their populations replicate as dynamic and complex mutant distributions, termed viral quasispecies. Repeated genetic bottlenecks, which experimentally are carried out through serial plaque-to-plaque transfers of the virus, lead to fitness decrease (measured here as diminished capacity to produce infectious progeny). Here we report an analysis of fitness evolution of several low fitness foot-and-mouth disease virus clones subjected to 50 plaque-to-plaque transfers. Unexpectedly, fitness decrease, rather than being continuous and monotonic, displayed a fluctuating pattern, which was influenced by both the virus and the state of the host cell as shown by effects of recent cell passage history. The amplitude of the fluctuations increased as fitness decreased, resulting in a remarkable resistance of virus to extinction. Whereas the frequency distribution of fitness in control (independent) experiments follows a log-normal distribution, the probability of fitness values in the evolving bottlenecked populations fitted a Weibull distribution. We suggest that multiple functions of viral genomic RNA and its encoded proteins, subjected to high mutational pressure, interact with cellular components to produce this nontrivial, fluctuating pattern.
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