ArticleJournal of autism and developmental disorders2003
Features of autism in Rett syndrome and severe mental retardation.
Article in Journal of autism and developmental disorders, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Caregiver- and Clinician-Reported Adaptive Functioning in Rett Syndrome: a Systematic Review and Evaluation of Measurement Strategies.Neuropsychology review · 2019Pooled it
- Case-control meta-analysis of blood DNA methylation and autism spectrum disorder.Molecular autism · 2018Pooled it
- Glutamatergic candidate genes in autism spectrum disorder: an overview.Journal of neural transmission (Vienna, Austria : 1996) · 2014Pooled it
- Rett Syndrome Behaviour Questionnaire: Variability of Scores and Related Factors.Journal of child and adolescent psychopharmacology · 2025Article
- Profiles of autism characteristics in thirteen genetic syndromes: a machine learning approach.Molecular autism · 2023Article
- Rett Syndrome andNeuropsychiatric disease and treatment · 2022Review
- Peripheral Somatosensory Neuron Dysfunction: Emerging Roles in Autism Spectrum Disorders.Neuroscience · 2020Review
- Comparative psychopharmacology of autism and psychotic-affective disorders suggests new targets for treatment.Evolution, medicine, and public health · 2019Review
- Key issues in Rett syndrome: emotional, behavioural and autonomic dysregulation (EBAD) - a target for clinical trials.Orphanet journal of rare diseases · 2018Review
- Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder.Molecular psychiatry · 2016Article
- Anxiety-like behavior in Rett syndrome: characteristics and assessment by anxiety scales.Journal of neurodevelopmental disorders · 2015Article
- Preclinical research in Rett syndrome: setting the foundation for translational success.Disease models & mechanisms · 2012Review
- The relationship of Rett syndrome and MECP2 disorders to autism.Dialogues in clinical neuroscience · 2012Review
- A mixed-methods investigation of sensory response patterns in Barth syndrome: a clinical phenotype?American journal of medical genetics. Part A · 2012Article
- Synaptic signaling and aberrant RNA splicing in autism spectrum disorders.Frontiers in synaptic neuroscience · 2011Article
- Medical conditions in autism spectrum disorders.Journal of neurodevelopmental disorders · 2009Article
- The diagnosis of autism in a female: could it be Rett syndrome?European journal of pediatrics · 2008Article
- Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome.Neurology · 2008Article
- The role of the neurobiologist in redefining the diagnosis of autism.Brain pathology (Zurich, Switzerland) · 2007Review
- Epilepsy in autism spectrum disorders.European child & adolescent psychiatry · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has long been recognized that there is phenotypic overlap between Rett syndrome (RS) and autism. Advances in our clinical and genetic understanding of RS over the past decade have made clear that the cause and course of RS and autism are distinct (except perhaps in a few cases). Despite this, further delineation of the phenotypic overlap between RS and autism is warranted to enhance clinical decision-making and to further understanding of neuropathological development in both disorders. The present study measured autistic symptoms using the Autism Behavior Checklist (ABC) in a sample of girls with RS and a comparison group of girls with severe and profound mental retardation (SMR). Controlling for developmental level and motor ability, girls with RS scored more highly than those with SMR on the Sensory and Relating subscales. In contrast, there were no group differences on the Body and Object use, Language and Social and Self-help subscales. Further work on the characterisation of the behavioral phenotype of genetic disorders such as RS and autism may aid in identifying the neuropathogenic processes that lead from gene-to-brain-to-behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.