ArticleJournal of clinical microbiology2003
Epidemiology and molecular characterization of Clostridium difficile strains from patients with diarrhea: low disease incidence and evidence of limited cross-infection in a Swedish teaching hospital.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Genomic surveillance ofmBio · 2024Article
- Impact of ribotype on Clostridioides difficile diagnostics.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Ribotype Classification ofFrontiers in microbiology · 2020Article
- Management of adult Clostridium difficile digestive contaminations: a literature review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- National Surveillance for Clostridioides difficile Infection, Sweden, 2009-2016.Emerging infectious diseases · 2018Article
- Emergence and spread of moxifloxacin-resistantNew microbes and new infections · 2016Article
- Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings.Emerging infectious diseases · 2016Article
- Fidaxomicin--the new drug for Clostridium difficile infection.The Indian journal of medical research · 2015Review
- Clostridium difficile in faeces from healthy dogs and dogs with diarrhea.Acta veterinaria Scandinavica · 2013Article
- Risk factors for Clostridium difficile toxin-positive diarrhea: a population-based prospective case-control study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Comparison of strain typing results for Clostridium difficile isolates from North America.Journal of clinical microbiology · 2011Article
- Impact of strain type on detection of toxigenic Clostridium difficile: comparison of molecular diagnostic and enzyme immunoassay approaches.Journal of clinical microbiology · 2010Article
- The changing epidemiology of Clostridium difficile infections.Clinical microbiology reviews · 2010Review
- Postoperative Clostridium difficile-associated diarrhea.Surgery · 2010Article
- Prevalence of diverticulosis in recurrent Clostridium difficile infection.World journal of gastroenterology · 2010Article
- Evaluation of tcdB real-time PCR in a three-step diagnostic algorithm for detection of toxigenic Clostridium difficile.Journal of clinical microbiology · 2010Article
- Injudicious antibiotic use leading to fulminating Clostridium difficile infection: a case report.Cases journal · 2009Article
- Diagnosis and treatment of acute or persistent diarrhea.Gastroenterology · 2009Review
- Increased sporulation rate of epidemic Clostridium difficile Type 027/NAP1.Journal of clinical microbiology · 2008Article
- Epidemiology of Clostridium difficile infection in a large teaching hospital in Singapore.Pathology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We prospectively studied the epidemiology of Clostridium difficile-associated diarrhea (CDAD) in a 900-bed hospital over the course of 12 months by PCR-ribotyping of C. difficile isolates. A total of 304 cases were diagnosed, corresponding to an overall incidence of 7/1,000 admissions, with higher rates in nephrology, hematology, and organ transplantation wards (37, 30, and 21/1,000), and 72% were classified as hospital associated (onset in hospital or onset at home but after a hospital stay within 2 months). All 382 isolates from 227 of 304 (75%) patients available for PCR-ribotyping were typeable, yielding 70 PCR-ribotypes. The three most common types comprised 30% of hospital-associated and 34% of community-associated cases, indicating import via admitted patients as a major source of C. difficile strains occurring in the hospital. Of the 227 patients studied, 38% each contributed 2 to 13 fecal samples positive for C. difficile over the course of the study period. Repeat isolates of the same PCR-ribotype as the first isolate were found in 79% of these patients and in 95% of specimens delivered within 30 days, compared to 63% of those obtained at 31 to 204 days. Nosocomial acquisition of CDAD, defined as the proportion of cases sharing C. difficile type and admitted to the same ward within 2 or 12 months, was 20% and 32% of hospital-associated cases and 14% and 23% of all cases, respectively. Thus, most CDAD cases diagnosed over the course of the study period, including those associated with hospitalization, appeared to be caused by endogenous C. difficile strains rather than by strains truly being acquired in the hospital.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.