ArticleActa psychiatrica Scandinavica2003
Postmaturity in a genetic subtype of schizophrenia.
Article in Acta psychiatrica Scandinavica, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Neonatal hypocalcemia, neonatal seizures, and intellectual disability in 22q11.2 deletion syndrome.Genetics in medicine : official journal of the American College of Medical Genetics · 2014Article
- Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era.The application of clinical genetics · 2012Article
- Association of schizophrenia in 22q11.2 deletion syndrome and gray matter volumetric deficits in the superior temporal gyrus.The American journal of psychiatry · 2011Article
- Neurocognitive profile in 22q11 deletion syndrome and schizophrenia.Schizophrenia research · 2006Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether postmaturity (gestation > 41 weeks), small for gestational age (SGA), and other pregnancy and birth complications that may elevate risk for neurodevelopmental disorders, are associated with elevated risk for schizophrenia in 22q11 Deletion Syndrome (22qDS), a genetic subtype of schizophrenia.
methodAntepartum and intrapartum features were examined in 20 adults with 22qDS-schizophrenia and three comparison groups: newborn encephalopathy (n = 164) and healthy newborn controls (n = 400) from Badawi et al.'s (Br Med J 1998, 317: 1549) study, and 16 non-psychotic 22qDS adults (22qDS-NP).
resultsPostmaturity (OR 13.0, 95% CI 3.95, 42.77; P < 0.001) and SGA (OR 3.59, 95% CI 1.23, 10.5; P = 0.03) were more prevalent in 22qDS-SZ than controls. Postmaturity was non-significantly more prevalent in 22qDS-SZ than in newborn encephalopathy (P = 0.06) or 22qDS-NP (P = 0.2). SGA showed similar rates in the two 22qDS groups and newborn encephalopathy, but was more prevalent in 22qDS-NP than controls (P = 0.05).
conclusionThe results suggest that postmaturity may be associated with expression of schizophrenia in a 22qDS subtype of schizophrenia. SGA may be a non-specific marker of neurodevelopmental disturbance.
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