ArticleMolecular and cellular biochemistry2003
The relationship between human cytomegalovirus infection and atherosclerosis development.
Article in Molecular and cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Human cytomegalovirus infection and coronary heart disease: a systematic review.Virology journal · 2018Pooled it
- Cytomegalovirus infection and coronary heart disease risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- The Role of CMV Infection in Primary Lesions, Development and Clinical Expression of Atherosclerosis.Journal of clinical medicine · 2022Review
- Association Between Cytomegalovirus Serostatus, Antiviral Therapy, and Allograft Survival in Pediatric Heart Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Don't Go Breaking My Heart: MCMV as a Model for HCMV-Associated Cardiovascular Diseases.Pathogens (Basel, Switzerland) · 2021Review
- Article
- Atherosclerosis prediction by microarray-based DNA methylation analysis.Experimental and therapeutic medicine · 2020Article
- Cellular reservoirs of latent cytomegaloviruses.Medical microbiology and immunology · 2019Review
- Infection and Atherosclerosis Development.Archives of medical research · 2015Review
- Shear stress upregulates IL-1β secretion by Chlamydia pneumoniae- infected monocytes.Biotechnology and bioengineering · 2015Article
- High prevalence of human cytomegalovirus in carotid atherosclerotic plaques obtained from Russian patients undergoing carotid endarterectomy.Herpesviridae · 2013Article
- Spontaneous resolution of intravitreal steroid-induced bilateral cytomegalovirus retinitis.Korean journal of ophthalmology : KJO · 2012Article
- Congenital cytomegalovirus infection: molecular mechanisms mediating viral pathogenesis.Infectious disorders drug targets · 2011Review
- Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors.Journal of thrombosis and thrombolysis · 2010Article
- The human eye (retina): a site of persistent HCMV infection?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2005Article
- Cytomegalovirus localization in atherosclerotic plaques is associated with acute coronary syndromes: report of 105 patients.Methodist DeBakey cardiovascular journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, increasing attention is being paid to the viral etiology of atherosclerosis (AS). Human cytomegalovirus (HCMV) is thought to be the most possible etiological factor of AS. In our study, artery vascular tissue specimens derived from 75 patients with AS were studied for detection of HCMV immediately early (IE) and later (L) gene fragments by polymerase chain reaction (PCR) and in situ hybridization; sera collected from the same patients were examined for HCMV specific IgG and IgM by enzyme-linked immunosorbent assay (ELISA). Twenty two normal arterial tissues and sera were used as controls. We found that the positive rate of HCMV L and IE gene fragments were significantly higher in AS patients than those in controls. HCMV DNA were mainly observed in nucleus of endothelial cells and muscularis under intima as well as smooth muscle of media of AS area, rarely found in controls. These results suggested that HCMV infection may relate to the pathogenesis of AS; and the artery itself may be the site of HCMV latency. In addition, higher levels of HCMV IgG and IgM were found to be associated with virus persistence, indicating that a periodically active latent infection or a continuously active infection is presented in AS patients.
Indexed as
Identifiers
12956403What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.